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We herein measured TUSC7 expression using RT\u2010qPCR and investigated its biological role in CLL through gain\u2010of\u2010function experiments. Our results revealed that TUSC7 expression was significantly lower in CLL patients compared to healthy controls, and its downregulation was associated with poor prognosis. Meanwhile, TUSC7 overexpression inhibited cell proliferation while promoting cell apoptosis. Mechanistically, TUSC7 interacted with miR\u2010211\u20105p, thereby regulating the downstream target gene, solute carrier family 37 member 3 (SLC37A3). Further rescue experiments demonstrated that silencing SLC37A3 or upregulating miR\u2010211\u20105p reversed the effects of TUSC7 elevation on cell proliferation and apoptosis. In conclusion, our findings suggest that TUSC7 regulates cell proliferation in CLL through the miR\u2010211\u20105p\/SLC37A3 axis.<\/jats:p>","DOI":"10.1002\/kjm2.70003","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T16:51:19Z","timestamp":1741625479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>LncRNA TUSC7<\/scp> Inhibits Cell Proliferation in Chronic Lymphocytic Leukemia by Modulating the <scp>miR<\/scp>\u2010211\u20105p\/<scp>SLC37A3<\/scp> Axis"],"prefix":"10.1002","volume":"41","author":[{"given":"Xu\u2010Li","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6513-5853","authenticated-orcid":false,"given":"Jia","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Pathology, the Second Hospital of Nanjing Affiliated to Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"issue":"42","key":"e_1_2_9_2_1","first-page":"2153","article-title":"Chronic Lymphocytic Leukemia","volume":"138","author":"Maurer C.","year":"2013","journal-title":"Deutsche Medizinische Wochenschrift"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30422-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-537498"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-044008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26367"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-021-00973-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.96"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.4087"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.1023"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-155721"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.06.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1199948"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026617666161116144744"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3378-5_21"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106706"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106564"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190291"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4414-y"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116549"},{"issue":"9","key":"e_1_2_9_22_1","first-page":"4026","article-title":"TUSC7 Acts as a Tumor Suppressor in Colorectal Cancer","volume":"9","author":"Ren W.","year":"2017","journal-title":"American Journal of Translational Research"},{"issue":"6","key":"e_1_2_9_23_1","first-page":"3386","article-title":"Overexpression of lncRNA TUSC7 Reduces Cell Migration and Invasion in Colorectal Cancer","volume":"41","author":"Zhang H.","year":"2019","journal-title":"Oncology Reports"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-018-0031-4"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051723"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111528"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2626-6"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-5946-0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.10.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0188-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103334"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S305865"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11994"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28248"},{"issue":"7","key":"e_1_2_9_35_1","first-page":"3749","article-title":"CircRNA EPB41L2 Inhibits Tumorigenicity of Lung Adenocarcinoma Through Regulating CDH4 by miR\u2010211\u20105p","volume":"24","author":"Zhang S. 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