{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:58:26Z","timestamp":1753869506225,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Spinal cord injury (SCI) triggers secondary damage, including pain\u2010induced hypertension, inflammation, and hemorrhage, impairing recovery. This study evaluated the efficacy of general anesthesia with preemptive propofol administration in mitigating secondary damage in SCI rats. SCI was induced in rats using a contusion model. Propofol (100\u2009mg\/kg) was administered intraperitoneally either 30\u2009min before (preemptive) or 30\u2009min after intermittent tail shock. Systolic blood pressure (SBP), body weight, food intake, inflammatory markers (interleukin\u20101 beta [IL\u20101\u03b2], interleukin\u20106 [IL\u20106]), hemorrhage markers, and serum levels of SCI biomarkers (glial fibrillary acidic protein [GFAP], myelin basic protein [MBP]) were measured. Functional recovery was assessed over 28\u2009days using the Basso, Beattie, and Bresnahan (BBB) scale, horizontal ladder test, and rotarod test. Preemptive propofol administration effectively mitigated pain\u2010induced hypertension, enhanced body weight and food intake, and reduced inflammatory markers to levels comparable to unstimulated SCI rats. In contrast, propofol administered post\u2010stimulation was less effective. Preemptive administration significantly decreased GFAP levels and preserved MBP levels. Importantly, preemptive intervention reduced levels of hemoglobin and alpha hemoglobin, while post\u2010stimulation intervention showed no significant effect on hemorrhage. Behavioral assessments demonstrated improved locomotor recovery, motor coordination, and balance in preemptively treated rats compared to delayed or no intervention. Preemptive administration of propofol effectively reduces pain\u2010induced hypertension, inflammation, and gliosis while preserving myelin integrity and enhancing functional recovery in SCI rats. This intervention demonstrates significantly greater efficacy compared to delayed administration, underscoring the critical importance of timely treatment in mitigating secondary damage and improving outcomes after SCI.<\/jats:p>","DOI":"10.1002\/kjm2.70011","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T11:04:00Z","timestamp":1743591840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preemptive Propofol Administration in Spinal Cord Injury: Effects on Pain\u2010Induced Hypertension, Neuroinflammation, and Functional Recovery in Rats"],"prefix":"10.1002","volume":"41","author":[{"given":"Qun","family":"Cheng","sequence":"first","affiliation":[{"name":"Anesthesiology Department The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital  Quzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang\u2010Yu","family":"Fang","sequence":"additional","affiliation":[{"name":"Anesthesiology Department The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital  Quzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9981-2752","authenticated-orcid":false,"given":"Rong\u2010En","family":"Qiu","sequence":"additional","affiliation":[{"name":"Anesthesiology Department The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital  Quzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cjtee.2023.05.002","article-title":"Advance in Hyperbaric Oxygen Therapy in Spinal Cord Injury","volume":"27","author":"Siglioccolo A.","year":"2024","journal-title":"Chinese Journal of Traumatology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.339475"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1084101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0449"},{"issue":"1","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03239","article-title":"Autonomic Dysregulation and Phenobarbital in Patients With Masked Primary Hypertension","volume":"6","author":"Bakkali M. 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