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This study aimed to investigate the genetic effects of risk single nucleotide polymorphisms (SNPs) on the occurrence of low BMD in patients with MASLD and HU, particularly focusing on relatively young or non\u2010obese populations. We conducted a cross\u2010sectional study utilizing data from the Taiwan Biobank, screening a total of 150,709 participants who were prospectively enrolled over a period of 13\u2009years. The risk SNPs for MASLD were identified. Genotype analyses of HU and its effects on the occurrence of low BMD in the general population were evaluated, with further analyses of common SNPs focusing on patients with MASLD, including subgroup analyses on relatively young and non\u2010obese populations. A total of 20,496 participants were eligible for analysis, including 7526 patients with MASLD. Several risk SNPs for MASLD were identified. Furthermore, MASLD patients carrying the PNPLA3\u2010rs738409 C_C, PNPLA3\u2010rs2896019 T_T, GCKR\u2010rs780094 T_T, and GCKR\u2010rs1260326 T_T genotypes exhibited an increased risk of comorbidity with HU. Trend analysis revealed that the T alleles in GCKR\u2010rs780094 and GCKR\u2010rs1260326 were associated with the occurrence of low BMD in MASLD individuals comorbid with HU, particularly among relatively young or non\u2010obese populations. In relatively young, non\u2010obese patients with MASLD and HU, genetic effects significantly increase the risk of occurrence of low BMD. Given the presence of genetic effects in these ostensibly low\u2010risk groups, heightened awareness and close follow\u2010up are recommended.<\/jats:p>","DOI":"10.1002\/kjm2.70017","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:10:56Z","timestamp":1744218656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>GCKR<\/scp> Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non\u2010Obese Patients With <scp>MASLD<\/scp> and Hyperuricemia"],"prefix":"10.1002","volume":"41","author":[{"given":"Tzu\u2010Hao","family":"Li","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"School of Medicine College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"School of Medicine Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Shin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Chen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Cheng","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine Taipei Veteran General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Yun","family":"Yeh","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Chin","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine, National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Chest Medicine Taipei Veterans General Hospital  Taipei 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