{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:15:11Z","timestamp":1785888911343,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Radiofrequency ablation (RFA) is increasingly recognized as a minimally invasive option for primary hyperparathyroidism (PHPT). This study aimed to evaluate the effectiveness and safety of ultrasound (US)\u2010guided RFA for the treatment of PHPT in Taiwan. We conducted a retrospective study of patients with PHPT who underwent RFA at a single medical center between March 2020 and January 2023. Serum biochemical samples, changes in parathyroid nodule volume, symptomatic scores, and complications were analyzed at follow\u2010up after RFA. The volume reduction ratio (VRR) and treatment response at 1\u2009year were evaluated. Among the 31 patients, 93.55% achieved a complete response with a VRR of 97.48% at 12\u2009months post\u2010RFA. Serum calcium and intact parathyroid hormone (iPTH) levels were significantly lower immediately after treatment than at baseline. However, a difference in phosphorus levels was noted 1\u2009week later, and the alkaline phosphatase (ALP) level was significantly decreased after 3\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Transient hoarseness occurred in three patients and resolved spontaneously within 6\u2009months. US\u2010guided RFA is effective and safe for treating PHPT, with a satisfactory VRR and treatment response. This approach could be an alternative to surgery for ineligible patients.<\/jats:p>","DOI":"10.1002\/kjm2.70022","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:55:23Z","timestamp":1747644923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Radiofrequency Ablation Safety and Efficacy in Primary Hyperparathyroidism: A Single\u2010Center Retrospective Study in Taiwan and Literature Review"],"prefix":"10.1002","volume":"41","author":[{"given":"Shu\u2010Ting","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Che","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic 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