{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T01:10:01Z","timestamp":1755825001588,"version":"3.44.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hepatitis C virus (HCV) infection is associated with an increased risk of cardiovascular disease (CVD); however, the impact of interferon (IFN)\u2010based therapy on cardiovascular outcomes remains unclear. This nationwide cohort study included 7411 patients with HCV from The Taiwanese Chronic Hepatitis C Cohort registry who received IFN\u2010based therapy between 2003 and 2014. Patients were categorized into sustained virological response (SVR) (<jats:italic>n<\/jats:italic>\u2009=\u20095785) and non\u2010SVR (<jats:italic>n<\/jats:italic>\u2009=\u20091676) groups. The incidence of new\u2010onset CVD events, including stroke, coronary artery disease, heart failure, and arrhythmia, was assessed using three Cox proportional hazard models adjusted for different sets of confounding factors. The cumulative CVD incidence was comparable in the SVR and non\u2010SVR groups (11.2% vs. 10.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.609). SVR was not significantly associated with a reduced overall CVD risk among the three models [hazards ratio (HR)\u2009=\u20090.88, 95% confidence interval (CI): 0.71\u20131.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.158]. However, a lower risk of stroke was observed in patients who achieved an SVR, although the difference was not significant (HR\u2009=\u20090.84, 95% CI: 0.74\u20130.94). The results of the sensitivity analyses confirmed these findings. An SVR following IFN\u2010based therapy did not substantially reduce the overall CVD risk; however, a potential reduction in stroke risk was observed. These results emphasize the importance of long\u2010term cardiovascular risk assessments and highlight the need for further research, particularly in the direct\u2010acting antiviral era in which increased cardiovascular benefits may be expected.<\/jats:p>","DOI":"10.1002\/kjm2.70036","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T04:34:28Z","timestamp":1748061268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Hepatitis C Virus Clearance on Cardiovascular Risk: A Real\u2010World Experience From the Nationwide Taiwan Hepatitis C Virus Registry"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-2569","authenticated-orcid":false,"given":"Ping\u2010Jen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology Shuang Ho Hospital, Taipei Medical University  New 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I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Horng","family":"Kao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-9707","authenticated-orcid":false,"given":"Chen\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical 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