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The successful injection of lentiviral vectors was verified by RT\u2010qPCR. The histopathology of foot ulcer tissues of DFU rats was observed by HE staining. Iron deposition was observed by Perls' Blue staining. Inflammatory factors were detected by ELISA. Protein expression of ferroptosis markers (GPX4 and SLC7A11) was measured by Western blot. The interaction of circ_0005654 with IGF2BP2 was verified by RNA pull\u2010down assay and RIP assay. Iron deposition and inflammatory factor levels were increased in foot ulcer tissues of DFU rats, and wound healing was impaired. Liproxstatin\u20101, a ferroptosis inhibitor, promoted wound healing in DFU rats by inhibiting ferroptosis and inflammation. circ_0005654 expression was up\u2010regulated. Down\u2010regulating circ_0005654 promoted wound healing in DFU rats by inhibiting ferroptosis and inflammation. circ_0005654 could interact with IGF2BP2, and up\u2010regulating IGF2BP2 attenuated the effects of circ_0005654 down\u2010regulation in DFU rats. circ_0005654 promotes ferroptosis to aggravate DFU by interacting with IGF2BP2.<\/jats:p>","DOI":"10.1002\/kjm2.70047","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:40:49Z","timestamp":1749724849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanistic Insights Into hsa_circ_0005654\u2010Induced Ferroptosis in Diabetic Foot Ulcers Through <scp>IGF2BP2<\/scp> Interaction"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2000-8635","authenticated-orcid":false,"given":"Chun\u2010Meng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery Wenzhou 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