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Non\u2010invasive follicular thyroid neoplasm with papillary\u2010like nuclear features (NIFTPs) was established as a distinct entity in the 2017 4th edition of the <jats:italic>WHO Classification of Tumors of Endocrine Organs<\/jats:italic> due to its indolent clinical behavior and excellent prognosis. These tumors are characterized by a well\u2010defined border, an exclusive follicular growth pattern, and PTC nuclear features. Molecularly, NIFTPs typically harbor <jats:italic>RAS<\/jats:italic> gene mutations, <jats:italic>PAX8\u2010PPARG<\/jats:italic> rearrangements, or <jats:italic>THADA<\/jats:italic> gene fusions. In the 2022 5th edition of the <jats:italic>WHO Classification<\/jats:italic>, subcentimeter NIFTPs and oncocytic NIFTPs were introduced as new subtypes. In this review, we summarize the epidemiology, ultrasound features, histology\/cytology, and molecular characteristics of NIFTP. As research continues to refine diagnostic criteria and management approaches, recognizing the distinct molecular and clinical features of NIFTP is essential for optimizing patient care and ensuring appropriate surgical management.<\/jats:p>","DOI":"10.1002\/kjm2.70051","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:43:59Z","timestamp":1748688239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non\u2010Invasive Follicular Thyroid Neoplasm With Papillary\u2010Like Nuclear Features (<scp>NIFTPs<\/scp>)"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6888-5736","authenticated-orcid":false,"given":"Howard Her\u2010Juing","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tieying","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1446"},{"key":"e_1_2_14_4_1","first-page":"78","volume-title":"WHO Classification of Tumours of Endocrine Ergans","author":"Nikiforov Y. 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