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In\u00a0vivo experiments were conducted to evaluate biochemical parameters in rats under different treatment conditions. Bone tissues underwent HE staining, and bone mineral density (BMD) along with key bone metabolism markers (\u03b2\u2010CTX, OC, SOST) were measured. The activities of antioxidant enzymes (SOD, GPX, CAT), oxidative stress indicators (MDA), and levels of inflammatory factors (MCP\u20101, IL\u20106, IL\u20101, TNF\u2010\u03b1) were also assessed. Western blot was used to analyze the expression of proteins associated with AGE\/RAGE signaling and the Wnt\/\u03b2\u2010catenin pathway. Morroniside increased trabecular bone quantity and quality, upregulated the bone formation markers OC and SOST, downregulated the bone resorption marker \u03b2\u2010CTX, and significantly increased BMD. Additionally, it modulated the systemic metabolic status by reducing fasting blood glucose (FBG), glycated hemoglobin (HbA1c), free fatty acids (FFA), triglycerides (TG), and total cholesterol (TC). Further research indicated that morroniside inhibited AGE\/RAGE signaling, mitigated oxidative stress and inflammatory responses, and enhanced Wnt\/\u03b2\u2010catenin pathway activity, thereby promoting osteoblast proliferation, differentiation, and mineralization. The introduction of DKK1 significantly attenuated these beneficial effects of morroniside, confirming its protective role through activation of the Wnt\/\u03b2\u2010catenin pathway. Morroniside exerts beneficial effects on bone metabolism and quality in DOP rats by regulating the AGEs\/RAGE\/Wnt\/\u03b2\u2010catenin signaling pathway, while also alleviating oxidative stress and inflammatory responses. These findings provide novel insights and potential therapeutic targets for the treatment of DOP.<\/jats:p>","DOI":"10.1002\/kjm2.70063","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:39:36Z","timestamp":1750941576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Morroniside Improves Diabetic Osteoporosis via the <scp>AGE<\/scp>\/<scp>RAGE<\/scp>\/Wnt\/\u03b2\u2010Catenin Signaling Pathway"],"prefix":"10.1002","volume":"41","author":[{"given":"Lu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Air Force Medical University  Xi'an 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