{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:24:45Z","timestamp":1793489085123,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sepsis\u2010associated acute kidney injury (SA\u2010AKI) is associated with morbidity and mortality. Ferroptosis is associated with the pathophysiology of SA\u2010AKI. Here, we investigated the role of LIM and cysteine\u2010rich domain 1 (LMCD1) in the regulation of ferroptosis during SA\u2010AKI progression. SA\u2010AKI models were established by CLP and LPS treatments. Hematoxylin and eosin (HE) and (PAS) staining were conducted to examine renal pathological changes. ELISA was used to measure serum creatinine and BUN levels. Lipid ROS levels in cells were examined using flow cytometry. MDA, GSH, SOD, and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    levels in the cells were measured using appropriate kits. Molecular interactions were analyzed using ChIP, a dual\u2010luciferase reporter gene, and Co\u2010IP assays. GATA1 knockdown inhibits LPS\u2010induced cell injury, oxidative stress, and ferroptosis in HK\u20102 cells by transcriptionally inhibiting LMCD1 expression. Moreover, LMCD1 activates the Hippo\/YAP pathway by promoting CUL3\u2010mediated Nrf2 ubiquitination degradation. LMCD1 knockdown alleviates CLP\u2010induced AKI in mice by inhibiting ferroptosis. Taken together, LMCD1 transcriptionally activated by GATA1 promotes ferroptosis during SA\u2010AKI progression by activating the Hippo\/YAP pathway and facilitating CUL3\u2010mediated Nrf2 ubiquitination degradation.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70071","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T14:49:23Z","timestamp":1752331763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>GATA1<\/scp>\n                    Transcriptionally Upregulates\n                    <scp>LMCD1<\/scp>\n                    , Promoting Ferroptosis in Sepsis\u2010Associated Acute Kidney Injury Through the Hippo\/\n                    <scp>YAP<\/scp>\n                    Pathway"],"prefix":"10.1002","volume":"41","author":[{"given":"You\u2010Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit Yiyang Central Hospital  Yiyang Hunan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Xia","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Yiyang Central Hospital  Yiyang Hunan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Fu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Yiyang Central Hospital  Yiyang Hunan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Yiyang Central Hospital  Yiyang Hunan Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Yiyang central Hospital  Yiyang Hunan Province People's Republic of 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