{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:19:29Z","timestamp":1784204369321,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011892","name":"Kaohsiung Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8P0281"],"award-info":[{"award-number":["CMRPG8P0281"]}],"id":[{"id":"10.13039\/501100011892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oral tongue squamous cell carcinoma (OTSCC) is an aggressive malignancy and the most common subsite of head and neck cancer among Taiwanese males. This study aimed to evaluate the prognostic significance of depth of invasion (DOI) in patients with node\u2010negative OTSCC treated with radical surgery alone. We retrospectively analyzed 243 patients with node\u2010negative OTSCC who had undergone radical surgery with adequate margins between 2005 and 2017. Each millimeter increase in DOI was significantly associated with a higher hazard of all\u2010cause mortality (ACM) (hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.03\u20131.111;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), cancer\u2010specific mortality (CSM) (HR, 1.087; 95% CI, 1.04\u20131.136;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and local recurrence (LR) (HR, 1.081; 95% CI, 1.021\u20131.145;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008), but not regional recurrence (RR) (HR, 1.042; 95% CI, 0.986\u20131.102;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.144). In multivariate analysis, DOI remained an independent predictor of ACM, CSM, and LR. A DOI\u2010based nomogram demonstrated improved predictive performance, with a concordance index of 0.700 for overall survival. In conclusion, DOI represents a crucial prognostic factor for ACM, CSM, and LR in patients with node\u2010negative OTSCC treated with surgery alone, highlighting its potential clinical utility for early risk stratification and guidance in decision\u2010making regarding adjuvant therapy or intensified surveillance.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70102","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:52:02Z","timestamp":1756731122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Depth of Invasion in Node\u2010Negative Oral Tongue Cancer Treated With Surgery Alone"],"prefix":"10.1002","volume":"42","author":[{"given":"Po\u2010Wen","family":"Hsiao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tsai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University College of Medicine  Taoyuan Taiwan"},{"name":"School of Medicine College of Medicine, National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"School of Medicine Chang Gung University College of Medicine  Taoyuan Taiwan"},{"name":"School of Medicine College of Medicine, National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yuan","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yen","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"Doctoral Program of Clinical and Experimental Medicine National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  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