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By analyzing 18 pairs of GC tissues and establishing in\u00a0vitro models (combining GLIS2 knockdown\/BGN overexpression with Wnt pathway modulators), we demonstrated that GLIS2 directly binds to the BGN promoter to enhance its transcription, thereby activating Wnt\/\u03b2\u2010catenin signaling and significantly promoting GC cell migration, invasion, and EMT. Functional rescue experiments confirmed that BGN overexpression reverses the inhibitory effects of GLIS2 knockdown, while the Wnt\/\u03b2\u2010catenin inhibitor XAV\u2010939 effectively blocks BGN's tumor\u2010promoting effects. These findings establish the crucial role of the GLIS2\u2010BGN\u2010Wnt\/\u03b2\u2010catenin axis in regulating GC EMT and identify novel potential therapeutic targets for GC treatment.<\/jats:p>","DOI":"10.1002\/kjm2.70103","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T07:54:02Z","timestamp":1757663642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>GLIS2<\/scp>\n                    Promotes Epithelial\u2010Mesenchymal Transition and Gastric Cancer Progression by Regulating\n                    <scp>BGN<\/scp>\n                    to Activate the Wnt\/\u03b2\u2010Catenin Pathway"],"prefix":"10.1002","volume":"42","author":[{"given":"Juan","family":"Yan","sequence":"first","affiliation":[{"name":"The Infection Control Office Hunan Cancer Hospital  Changsha Hunan Province People's Republic of 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