{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:15:00Z","timestamp":1785813300441,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vitexin, an apigenin flavone glycoside, exhibits antitumor activity against various cancers including leukemia. Hypoxia enhances glycolysis, thereby promoting tumor growth. In this study, we aimed to explore the effects of vitexin on hypoxia\u2010induced growth and glycolysis in acute myeloid leukemia (AML) cells and determine the underlying molecular mechanisms. Our findings showed that vitexin inhibited the hypoxia\u2010induced increase in viability and proliferation of AML cells. Vitexin suppressed glucose uptake, lactate production, and the expression of hexokinase 2, pyruvate kinase M2, and lactate dehydrogenase A in hypoxia\u2010exposed AML cells. Vitexin also blocked the hypoxia\u2010induced increase in hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1) and Yes\u2010associated protein (YAP) expression, as well as the decrease in p\u2010YAP expression. In addition, our results demonstrate that the YAP pathway is regulated by HIF\u20101\u03b1 in hypoxia\u2010exposed AML cells and participates in the inhibitory effects of vitexin on hypoxia\u2010induced AML cell growth and glycolysis. These results indicate that vitexin prevents hypoxia\u2010induced growth and glycolysis in AML cells by regulating the HIF\u20101\u03b1\/YAP signaling pathway.<\/jats:p>","DOI":"10.1002\/kjm2.70111","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T04:20:17Z","timestamp":1758860417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitexin Attenuates the Growth and Glycolysis of Acute Myeloid Leukemia Cells by Suppressing the\n                    <scp>HIF<\/scp>\n                    \u20101\u03b1\u2010Modulated\n                    <scp>YAP<\/scp>\n                    Pathway Under Hypoxic Conditions"],"prefix":"10.1002","volume":"42","author":[{"given":"Ping","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematopathology People\u2032s Hospital of Chongqing Banan District  Chongqing 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