{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:40:27Z","timestamp":1788813627003,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study investigated the mechanism of miR\u2010127\u20103p in tumor cell stemness and docetaxel (DTX) resistance in triple\u2010negative breast cancer (TNBC). hsa\u2010miR\u2010127\u20103p and KIF3B levels were predicted using databases and validated in TNBC and paracancerous tissues. KM survival curves were plotted to analyze the effect of miR\u2010127\u20103p on patient survival. Pearson's analysis was used to determine the correlation between miR\u2010127\u20103p and KIF3B mRNA in cancer tissues. Drug\u2010resistant TNBC cell lines were established. After transfection, the cell viability, IC50, proliferation, migration, invasion, DTX resistance, apoptosis, and expression of the stemness markers SOX2, OCT4, and Nanog were detected. Databases were used to predict the downstream targets of miR\u2010127\u20103p. The starBase database and dual\u2010luciferase assay were used to predict and validate the binding relationship of miR\u2010127\u20103p with KIF3B. Finally, the effect of miR\u2010127\u20103p on transplanted tumors in TNBC nude mice was verified. miR\u2010127\u20103p was expressed at low levels in TNBC tissues and was notably associated with shorter survival. Upregulation of miR\u2010127\u20103p reduced TNBC cell stemness and DTX resistance. miR\u2010127\u20103p targeted KIF3B. KIF3B overexpression averted the effect of miR\u2010127\u20103p. miR\u2010127\u20103p inhibited the growth of transplanted tumors in TNBC nude mice. Overall, miR\u2010127\u20103p targets KIF3B, thereby reducing TNBC cell stemness and reversing DTX resistance.<\/jats:p>","DOI":"10.1002\/kjm2.70113","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:57:14Z","timestamp":1761749834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>miR<\/scp>\n                    \u2010127\u20103p Inhibits Cell Stemness and Docetaxel Resistance in Triple\u2010Negative Breast Cancer by Targeting\n                    <scp>KIF3B<\/scp>"],"prefix":"10.1002","volume":"42","author":[{"given":"Zi\u2010Chao","family":"He","sequence":"first","affiliation":[{"name":"Department of General Surgery The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2021.0459"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042420-093238"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01296-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01341-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104516"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.604124"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.02.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23063"},{"issue":"20","key":"e_1_2_8_10_1","first-page":"10383","article-title":"MiR\u2010127\u20103p Inhibits Proliferation of Ovarian Cancer in Rats Through Down\u2010Regulating MAPK4","volume":"24","author":"Du S. 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