{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:09:19Z","timestamp":1778324959146,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013460","name":"Taiwan Liver Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrahepatic cholangiocarcinoma (ICC) patients signed the informed consents. Most HCC participants (97%) had failed in tyrosine kinase inhibitor (TKI) and\/or immunotherapy before entering the study. Colchicine was started from 1\u2009mg twice per day and was adjusted ranging from 1.5 to 3\u2009mg\/day. One treatment cycle was defined as four continuous treatment days followed by 3\u2009days off. The HCC control group was matched to the same condition (Child score, tumor staging, previous TKI, and\/or immunotherapy) as the participants at a ratio of 3 to 1 (control to colchicine). The ICC control group was matched to the same tumor staging as the participants. The primary objective was to compare the survival between the two groups. The safety objective was to observe the adverse events of colchicine. The colchicine HCC group demonstrated longer median survival (283\u2009days) than the control group (107\u2009days) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001, 95% confidence interval 2.001\u20133.289, hazard ratio 0.3513, 95% confidence interval 0.2611\u20130.5523). Two ICC participants survived 491 and 461\u2009days, respectively, compared to the control group with a median survival of 8.5\u2009months and a 41.5% one\u2010year survival rate. Diarrhea (5%) was the only directly colchicine\u2010related grade 3\u20134 adverse event. In conclusion, this colchicine dosage schedule is clinically feasible as an effective palliative treatment for patients with primary hepatic malignancy unable to receive curative treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT04264260.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70121","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:26:10Z","timestamp":1758968770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase\n                    <scp>IIb<\/scp>\n                    Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8489-7147","authenticated-orcid":false,"given":"Zu\u2010Yau","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary Medicine, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Faculty of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Faculty of Post\u2010Baccalaureate Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Cancer Research Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University  Kaohsiung 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Internal Medicine Kaohsiung Medical University Gangshan Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Medicine, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Faculty of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-7051","authenticated-orcid":false,"given":"Jee\u2010Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Medicine, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Faculty of Medicine, College of Medicine 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