{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:59:27Z","timestamp":1780639167864,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study evaluated the prognostic value of the C\u2010PLAN index in advanced esophageal squamous cell carcinoma (ESCC) patients receiving immune checkpoint inhibitor (ICI) therapy. A retrospective analysis of 241 eligible patients treated during February 2020 to January 2023 was conducted. Based on the C\u2010PLAN index, calculated from lactate dehydrogenase (LDH), C\u2010reactive protein (CRP), performance status (PS), albumin (ALB), and derived neutrophil\u2010to\u2010lymphocyte ratio (dNLR), patients were categorized into Good (0\u20131 points) and Poor (2\u20135 points) groups. The Poor group exhibited more advanced clinical stages and larger tumor diameters (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The Good group demonstrated a significantly higher objective response rate and disease control rate (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), lower progression\/death incidence (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and longer progression\u2010free survival and overall survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Multifactorial Cox regression analysis revealed that PD\u2010L1 CPS &lt; 10%, clinical stage IV, and high C\u2010PLAN score (2\u20135 points) were independent risk factors for disease progression or death following ICI therapy in patients with advanced ESCC. The C\u2010PLAN index effectively stratifies prognosis and optimizes therapeutic decision\u2010making for advanced ESCC. The C\u2010PLAN index serves as a prognostic factor, providing an objective basis for survival assessment and treatment plan optimization in advanced ESCC patients.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70140","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T12:20:17Z","timestamp":1764850817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of the C\u2010\n                    <scp>PLAN<\/scp>\n                    Index in Advanced Esophageal Squamous Cell Carcinoma Patients Treated With Immune Checkpoint Inhibitors"],"prefix":"10.1002","volume":"42","author":[{"given":"Yi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Guangyuan Central Hospital  Guangyuan Sichuan 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