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Using a permanent middle cerebral artery occlusion (pMCAO) mouse model, we combined behavioral tests (rotarod and ladder rung) with electron microscopy, Western blotting (LC3B, p62, mTOR\/p\u2010mTOR), and ELISA (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106) to assess motor function, ultrastructural changes, autophagy, and neuroinflammation. Results demonstrated that EE significantly improved cerebellar\u2010mediated motor coordination, reduced neuronal degeneration, and preserved mitochondrial integrity, while enhancing autophagic activity via increased LC3B expression and decreased p62 accumulation. Ultrastructural analysis revealed elevated synaptic density and a shift toward mitochondrial rejuvenation, paralleled by attenuated neuroinflammatory responses and suppressed pro\u2010inflammatory cytokine levels, consistent with mTOR pathway inhibition. These findings indicate that EE promotes motor recovery by activating a self\u2010reinforcing repair loop in the DN, wherein autophagy\u2010mediated mitochondrial clearance and neuroinflammation suppression create a permissive microenvironment for synaptic remodeling, thereby establishing the DN as a pivotal hub for EE's therapeutic effects and supporting combinatory strategies targeting autophagy\u2013mitochondrial pathways to optimize rehabilitation.<\/jats:p>","DOI":"10.1002\/kjm2.70167","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:12:23Z","timestamp":1767611543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enriched Environment Enhances Motor Function in Mice With Cerebral Infarction by Promoting\n                    <scp>mTOR<\/scp>\n                    \u2010Dependent Autophagy in the Contralateral Dentate Nucleus"],"prefix":"10.1002","volume":"42","author":[{"given":"Chuan\u2010Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Jinshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-9244","authenticated-orcid":false,"given":"Jun\u2010Fa","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4647-2874","authenticated-orcid":false,"given":"Feng","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Jinshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70150-4"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.297084"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20200081"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112309"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968310380926"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.03.004"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy084"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01189"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa270"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315030"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-020-00595-z"},{"issue":"1","key":"e_1_2_13_13_1","first-page":"531","article-title":"Metabolic Alterations in the Rat Cerebellum Following Acute Middle Cerebral Artery Occlusion, as Determined by 1H NMR Spectroscopy","volume":"17","author":"Hu Z. 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