{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:18:10Z","timestamp":1786123090323,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to compare efficacy and safety of ultrasound\u2010guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB\u2010LB or ESPB\u2010CB; both groups received standardized gabapentin. The primary outcome was resting pain assessed by Numeric Rating Scale (NRS). Secondary outcomes were 72\u2010h event\u2010free time (time to first rescue medication or resting NRS \u2265\u20094), cumulative rescue opioid exposure in morphine milligram equivalents (MME), sleep by the Pittsburgh Sleep Quality Index (PSQI), health\u2010related quality of life by the Patient\u2010Reported Outcomes Measurement Information System (PROMIS), Patient Global Impression of Change (PGIC), and adverse events (AEs). ESPB\u2010LB achieved lower resting NRS at day 1, day 3 and day 7 (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), with no between\u2010group differences at day 30 or day 60. Event\u2010free time favored LB (median 54.10\u2009h vs. 18.95\u2009h; log\u2010rank\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.002). LB reduced cumulative MME at 48\u2009h and 72\u2009h, with convergence by days 7\u201360. PGIC favored LB at days 7 and 30, converging by day 60. Sleep and health\u2010related quality of life improved similarly with no between\u2010group differences; AEs were comparable, and no serious events occurred through day 60. In PHN, ESPB\u2010LB plus gabapentin provided an early advantage characterized by superior early analgesia, higher early responder rates, longer opioid\u2010free analgesia within 72\u2009h, and short\u2010term opioid sparing versus ESPB\u2010CB, while longer\u2010term outcomes and safety profiles were similar between groups.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70169","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:23:40Z","timestamp":1768292620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia"],"prefix":"10.1002","volume":"42","author":[{"given":"Xia\u2010Jing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Quzhou Second People's Hospital  Quzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Quzhou Second People's Hospital  Quzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u2010Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Quzhou Second People's Hospital  Quzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4847-4040","authenticated-orcid":false,"given":"Xiang\u2010Yu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital  Quzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Herpes Zoster","author":"Nair P. 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