{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:09:41Z","timestamp":1788844181135,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS\u2010stimulated BEAS\u20102B and HBEC3\u2010KT cells as well as cecal ligation and puncture (CLP)\u2010induced ALI models in C57BL\/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury characterized by reduced viability, enhanced apoptosis, increased cytokine secretion, and aggravated lung damage. Mechanistic studies combining dual\u2010luciferase and RIP assays revealed that NORAD directly bound miR\u2010150\u20105p to derepress STAT1, leading to elevated STAT1, p\u2010STAT1, and p\u2010p65 levels and activation of JAK\/STAT and NF\u2010\u03baB signaling. Silencing NORAD alleviated lung injury in\u00a0vitro and in\u00a0vivo, as evidenced by improved cell survival, decreased concentration of total protein in bronchoalveolar lavage fluid (BALF), reduced inflammatory response, lower wet\/dry (W\/D) ratio, diminished caspase\u20103 levels, and decreased histological injury scores in CLP mice. Furthermore, knockdown of miR\u2010150\u20105p or overexpression of STAT1 abolished the protective effects of NORAD inhibition, whereas overexpression of miR\u2010150\u20105p or knockdown of STAT1 mitigated the injury\u2010promoting effects of NORAD overexpression. These findings demonstrate that NORAD exacerbates sepsis\u2010induced ALI via the miR\u2010150\u20105p\/STAT1 axis, providing new insights into potential therapeutic targets for sepsis\u2010related lung injury.<\/jats:p>","DOI":"10.1002\/kjm2.70191","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:52:23Z","timestamp":1772981543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>LncRNA NORAD<\/scp>\n                    Enhances Inflammatory Injury in Sepsis\u2010Associated Acute Lung Damage Through\n                    <scp>miR<\/scp>\n                    \u2010150\u20105p\/\n                    <scp>STAT1<\/scp>\n                    \u2010Dependent\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Activation"],"prefix":"10.1002","volume":"42","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Jiujiang City Key Laboratory of Cell Therapy Jiujiang No. 1 People's Hospital  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency, Jiujiang City Key Laboratory of Cell Therapy Jiujiang No. 1 People's Hospital  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui\u2010Hua","family":"Wei","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Jiujiang City Key Laboratory of Cell Therapy Jiujiang No. 1 People's Hospital  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Jiujiang City Key Laboratory of Cell Therapy Jiujiang No. 1 People's Hospital  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2273-9326","authenticated-orcid":false,"given":"Hai\u2010Yan","family":"Zong","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Jiujiang City Key Laboratory of Cell Therapy Jiujiang No. 1 People's Hospital  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000958"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.779620"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.5.1303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000149854.61192.DC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000057841.33876.B1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6362344"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S436271"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-022-00687-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2018.12.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-1084-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2021.1928693"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-06032-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.701628"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-021-01500-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S315985"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155844"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-021-03685-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1031-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S400985"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102953"},{"issue":"6","key":"e_1_2_8_22_1","first-page":"1153","article-title":"Jaks, STATs, Cytokines, and Sepsis","volume":"9","author":"Scott M. 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