{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:54:40Z","timestamp":1791539680331,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560378"],"award-info":[{"award-number":["82560378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The triglyceride\u2010glucose (TyG) index, a marker of insulin resistance, is associated with outcomes in critical illness; however, its predictive role for 28\u2010day mortality in Asian patients with sepsis has not been established. To address this, the current investigation was designed to evaluate its prognostic significance and to construct a risk prediction model for short\u2010term mortality. This retrospective study analyzed sepsis patients admitted to the intensive care unit (ICU) of the Second Hospital of Lanzhou University from January 1, 2018 to December 31, 2023. Participants were randomly split into training\/validation cohorts (7:3 ratio). Multivariate logistic regression identified independent predictors. A nomogram was constructed by these predictors and it was validated using ROC curves (ROC), calibration plots, and decision curve analysis (DCA). A nomogram integrating seven variables\u2014age, respiratory failure within 48\u2009h, multiple organ dysfunction syndrome (MODS) within 48\u2009h, international normalized ratio (INR), lactate level, prognostic nutrition index (PNI), and TyG index\u2014predicted 28\u2010day mortality with AUCs of 0.855 (training, 95% CI: 0.818\u20130.891) and 0.826 (validation, 95% CI: 0.764\u20130.887), outperforming SOFA and APACHE II scores. Calibration curves confirmed alignment with actual outcomes, and DCA demonstrated broad clinical utility. The TyG index is an independent predictor of 28\u2010day sepsis mortality. The validated nomogram based on the TyG index enhances risk stratification, aiding clinicians in early decision\u2010making to improve patient outcomes and care quality.<\/jats:p>","DOI":"10.1002\/kjm2.70199","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:24:35Z","timestamp":1775190275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Triglyceride\u2010Glucose Index\u2010Based Nomogram for Predicting Short\u2010Term Mortality in Sepsis Patients"],"prefix":"10.1002","volume":"42","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine The Second Hospital &amp; Clinical Medical School, Lanzhou University  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The 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