{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:54:38Z","timestamp":1791539678897,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007071","name":"Harran \u00dcniversitesi","doi-asserted-by":"publisher","award":["22169"],"award-info":[{"award-number":["22169"]}],"id":[{"id":"10.13039\/501100007071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Contrast\u2010induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine\u2010learning\u2010based prediction of renal injury using histopathological, biochemical, and inflammatory markers. Thirty\u2010six female Wistar albino rats were randomized into control, riociguat, CIN model, and CIN\u2009+\u2009riociguat groups. CIN was induced by iohexol after dehydration, and riociguat was administered orally for 5\u2009days. Renal injury was assessed by histopathological scoring, TUNEL assay, and biochemical parameters including serum creatinine, urea, tumor necrosis factor\u2010alpha, nitric oxide, neutrophil gelatinase\u2010associated lipocalin, and advanced oxidation protein products. Riociguat significantly decreased serum creatinine, urea, apoptotic index, and histopathological injury scores, reduced inflammatory and oxidative stress markers, and increased nitric oxide levels compared with untreated CIN animals (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Machine learning models (Random Forest, CatBoost, AdaBoost, and XGBoost) were applied for exploratory prediction and feature importance analysis. The apoptotic index and nitric oxide were identified as dominant predictors, indicating mechanistic relevance but limited clinical screening utility because these predictors require histological assessment. Overall, riociguat demonstrated significant renoprotective effects through anti\u2010apoptotic, anti\u2010inflammatory, and antioxidative mechanisms, and machine learning provided hypothesis\u2010generating insight rather than a clinically deployable predictive model.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70201","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:27:38Z","timestamp":1773808058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Riociguat Against Contrast\u2010Induced Nephropathy: An Experimental and Machine Learning\u2010Based Study in Rats"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-6631","authenticated-orcid":false,"given":"Mustafa Begenc","family":"Tascanov","sequence":"first","affiliation":[{"name":"Department of Cardiology Samsun University, Faculty of Medicine  Samsun Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Turedi","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulkif","family":"Tanr\u0131verdi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necip Faz\u0131l","family":"Dedeoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sanl\u0131urfa Training and Research Hospital  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Fedai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuman","family":"Bicer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim Halil","family":"Alt\u0131parmak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep","family":"Demirbag","sequence":"additional","affiliation":[{"name":"Department of Cardiology Harran University, Faculty of Medicine  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-3933","authenticated-orcid":false,"given":"Gencay","family":"Sar\u0131\u0131s\u0131k","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering Harran University, Faculty of Engineering  Sanliurfa Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.04.047"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"47","article-title":"Relationship Between Basal Liver Function Test Levels and Contrast\u2010Induced Nephropathy in Patients Undergoing Coronary Angiography: Basal 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