{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:54:40Z","timestamp":1791539680320,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010110\u2010005\u2010MY3"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010110\u2010005\u2010MY3"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSYSU\u2010KMU\u2010114\u2010P32"],"award-info":[{"award-number":["NSYSU\u2010KMU\u2010114\u2010P32"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010037\u2010061"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010037\u2010061"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSTC 114\u20102314\u2010B\u2010037\u2010102\u2010MY2"],"award-info":[{"award-number":["NSTC 114\u20102314\u2010B\u2010037\u2010102\u2010MY2"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH111\u20101R03"],"award-info":[{"award-number":["KMUH111\u20101R03"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH112\u20102R08"],"award-info":[{"award-number":["KMUH112\u20102R08"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Patients with chronic hepatitis C (CHC) frequently present with steatotic liver disease (SLD) and cardiometabolic risk factors (CMRFs). This study aimed to evaluate the impact of SLD and CMRFs on liver\u2010related outcomes (LROs) in CHC patients after HCV eradication. This study evaluated 21,972 CHC patients who received curative antivirals in Taiwan. LROs included newly developed hepatocellular carcinoma and liver decompensation. During a follow\u2010up period of 71,000 person\u2010years (PYs), 745 (3.4%) patients developed LROs (annual incidence of 1.05%). The annual incidence of LRO (136.2 vs. 80.7 per 10,000 PYs,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) was significantly higher in patients without SLD than in those with SLD. Cox regression analysis revealed that SLD was independently associated with a lower risk of LRO (adjusted hazard ratio [aHR]\/95% confidence intervals [CI]: 0.85\/0.73\u20130.99,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038). There was an increased trend toward increased LRO risk in patients with a higher number of CMRFs than in those without CMRFs (aHR\/CI: 1.35\/1.02\u20131.78, 1.48\/1.11\u20131.97, and 1.53\/1.15\u20132.05 for 1, 2, and &gt;\u20093 CMRFs, respectively). Non\u2010SLD patients who carried CMRFs were independently associated with a high risk of LROs compared to SLD patients without any CMRF carriage (aHR\/CI: 1.97\/1.11\u20133.50,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). We concluded that CMRF burden had a dose\u2010dependent effect on LRO risk in CHC patients after curative antivirals. Non\u2010SLD CHC patients who possessed CMRFs were at a greater risk of LROs.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70214","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:41:04Z","timestamp":1776922864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Cardiometabolic Risk Factors and Steatotic Liver Disease on Liver\u2010Related Outcomes in Patients With Chronic Hepatitis C After Curative Antiviral Therapy"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"first","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center of Metabolic Disorders and Obesity Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Ph.D. Program in Translational Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung, and Academia Sinica Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5044-6727","authenticated-orcid":false,"given":"Pei\u2010Chien","family":"Tsai","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-7618","authenticated-orcid":false,"given":"Ming\u2010Lun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center of Metabolic Disorders and Obesity Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat\u2010sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center of Metabolic Disorders and Obesity Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-130X","authenticated-orcid":false,"given":"Tyng\u2010Yuan","family":"Jang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center of Metabolic Disorders and Obesity Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-6604","authenticated-orcid":false,"given":"Po\u2010Cheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ju","family":"Wei","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center of Metabolic Disorders and Obesity Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2010Jen","family":"Hou","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Municipal Gangshan Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Kuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-7051","authenticated-orcid":false,"given":"Jee\u2010Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center of Metabolic Disorders and Obesity Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yen","family":"Dai","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center of Metabolic Disorders and Obesity Kaohsiung Medical University  Kaohsiung 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Impact of Steatosis on Chronic Hepatitis C Progression and Response to Antiviral Treatments","volume":"9","author":"Siphepho P. 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