{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:03:32Z","timestamp":1781701412392,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This retrospective study aimed to explore the value of DAT\u2010FAT serological profiles confirmed by AET in classifying neonatal jaundice, evaluating its severity, and guiding clinical management. A total of 915 jaundiced newborns (584 pathological, 331 physiological) admitted from July 2018 to August 2021 were included. Univariate and multivariate logistic regression analyses were conducted to identify risk factors. To assess predictive ability for jaundice type and early risk stratification of jaundice severity, the 426 patients with ABO incompatibility were stratified into subgroups based on the results of the DAT\u2010FAT\u2010AET serological panel. Maternal pregnancy count, gestational weeks, direct bilirubin at admission, and ABO incompatibility were identified as independent predictors of jaundice type (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Those who tested triple\u2010positive in the DAT\u2010FAT\u2010AET serological panel (Group 2) had the highest predictive value for pathological jaundice (area under the curve, 0.920 [0.788\u20130.994]), indicating the maximum severity of pathological jaundice (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). AET serves as the definitive criterion for confirming ABO\u2010incompatible jaundice, while DAT\u2010FAT profiles enable early risk stratification of severity. Subgrouping by AET\u2010confirmed DAT\u2010FAT serology helps assess etiology and severity in ABO\u2010incompatible neonatal jaundice, supporting clinical early risk stratification.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70253","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:32:01Z","timestamp":1781699521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Study on Neonatal Jaundice: Early Risk Stratification Value of\n                    <scp>DAT<\/scp>\n                    \u2010\n                    <scp>FAT<\/scp>\n                    Serological Profiles Confirmed by\n                    <scp>AET<\/scp>"],"prefix":"10.1002","author":[{"given":"Tian\u2010Ge","family":"Wu","sequence":"first","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7514-930X","authenticated-orcid":false,"given":"Zhong\u2010Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6955-6410","authenticated-orcid":false,"given":"Li\u2010Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7422-2618","authenticated-orcid":false,"given":"Ming\u2010Hao","family":"Shi","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Department The Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41372-018-0048-4","article-title":"ABO Hemolytic Disease of the Fetus and Newborn: Thirteen Years of Data After Implementing a Universal Bilirubin Screening and Management Program","volume":"38","author":"Christensen R. D.","year":"2018","journal-title":"Journal of Perinatology: Official Journal of the California Perinatal Association"},{"issue":"9","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/vox.13327","article-title":"The Spectrum of ABO Haemolytic Disease of the Fetus and Newborn in Neonates Born to Group O Mothers","volume":"117","author":"Talwar M.","year":"2022","journal-title":"Vox Sanguinis"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1265739","article-title":"Clinical Value of Combined Predictors of RET%, \u03b3\u2010GT, LDH in the ABO Neonatal Hemolytic Disease","volume":"11","author":"Liu X.","year":"2023","journal-title":"Frontiers in Pediatrics"},{"issue":"6","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1542\/peds.2015-2001","article-title":"Predicting Nonhemolytic Neonatal Hyperbilirubinemia","volume":"136","author":"Norman M.","year":"2015","journal-title":"Pediatrics"},{"issue":"3","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12519-020-00347-3","article-title":"Management Strategies of Neonatal Jaundice During the Coronavirus Disease 2019 Outbreak","volume":"16","author":"Ma X. L.","year":"2020","journal-title":"World Journal of Pediatrics: WJP"},{"issue":"4","key":"e_1_2_11_7_1","article-title":"Single Versus Double Volume Exchange Transfusion in Jaundiced Newborn Infants","volume":"2006","author":"Thayyil S.","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7803175","article-title":"Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case\u2010Control Study","volume":"2018","author":"Zhou J.","year":"2018","journal-title":"BioMed Research International"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.diabres.2018.08.019","article-title":"Pre\u2010Pregnancy Obesity, Gestational Diabetes or Gestational Weight Gain: Which Is the Strongest Predictor of Pregnancy Outcomes?","volume":"144","author":"Bianchi C.","year":"2018","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"3","key":"e_1_2_11_10_1","first-page":"270","article-title":"Clinical and Biochemical Characteristics of Infants With Prolonged Neonatal Jaundice","volume":"24","author":"Siu S. 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M.","year":"2023","journal-title":"Journal of Perinatology: Official Journal of the California Perinatal Association"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.70253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/kjm2.70253","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.70253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:32:05Z","timestamp":1781699525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/kjm2.70253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":27,"alternative-id":["10.1002\/kjm2.70253"],"URL":"https:\/\/doi.org\/10.1002\/kjm2.70253","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70253"}}