{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:08:49Z","timestamp":1785323329147,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Renal dysfunction frequently occurs in patients with portal hypertension and is linked to unfavorable clinical outcomes. Transjugular intrahepatic portosystemic shunt (TIPS) has the potential to enhance renal perfusion through portal decompression; however, factors predicting early improvement in renal function remain insufficiently defined. This retrospective, single\u2010center study analyzed 188 consecutive patients with portal hypertension who underwent TIPS. Patients receiving renal replacement therapy or with baseline eGFR &lt;\u200915\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    were excluded. The primary endpoint was early renal function improvement, defined as a &gt;\u200910% reduction in serum creatinine within 7\u2009days. Early renal function improvement was observed in 27.7% of the cohort. Lower baseline eGFR was independently associated with higher probability of improvement (adjusted OR: 0.980, 95% CI: 0.966\u20130.993;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Neither pre\u2010 nor post\u2010TIPS portal venous pressure nor the magnitude of pressure reduction was significantly associated with renal response. Restricted cubic spline analysis indicated a linear inverse relationship between baseline eGFR and improvement probability. The multivariable model demonstrated modest discriminative ability (AUC 0.666). Baseline renal function was associated with early post\u2010TIPS early renal function improvement, whereas intra\u2010procedural portal pressure parameters were not predictive. These findings suggest that early renal function improvement following TIPS may predominantly reflect reversible functional impairment rather than established structural kidney injury.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70268","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:57:42Z","timestamp":1785322662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Early Renal Function Recovery After\n                    <scp>TIPS<\/scp>\n                    in Patients With Portal Hypertension"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-6140","authenticated-orcid":false,"given":"Meng","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Nephrology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nephrology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Yang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010You","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-4479","authenticated-orcid":false,"given":"Ye","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nephrology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"10308","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver Cirrhosis","volume":"398","author":"Gin\u00e8s P.","year":"2021","journal-title":"Lancet"},{"issue":"18","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2023.5997","article-title":"Diagnosis and Management of Cirrhosis and Its Complications: A Review","volume":"329","author":"Tapper E. B.","year":"2023","journal-title":"Journal of the American Medical Association"},{"issue":"1","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev-med-050223-112947","article-title":"Update on Hepatorenal Syndrome: From Pathophysiology to Treatment","volume":"76","author":"Khemichian S.","year":"2025","journal-title":"Annual Review of Medicine"},{"issue":"1","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jhep.2024.03.031","article-title":"Acute Kidney Injury in Patients With Cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) Joint Multidisciplinary Consensus Meeting","volume":"81","author":"Nadim M. K.","year":"2024","journal-title":"Journal of Hepatology"},{"issue":"8","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJMra2215289","article-title":"Acute Kidney Injury in Patients With Cirrhosis","volume":"388","author":"Nadim M. K.","year":"2023","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1007\/s00270-024-03866-y","article-title":"CIRSE Standards of Practice on Transjugular Intrahepatic Portosystemic Shunts","volume":"47","author":"Lucatelli P.","year":"2024","journal-title":"Cardiovascular and Interventional Radiology"},{"issue":"2","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3350\/cmh.2021.0239","article-title":"The Role of Transjugular Intrahepatic Portosystemic Shunt in Patients With Portal Hypertension: Advantages and Pitfalls","volume":"28","author":"Lee H. L.","year":"2022","journal-title":"Clinical and Molecular Hepatology"},{"issue":"1","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jhep.2025.01.029","article-title":"EASL Clinical Practice Guidelines on TIPS","volume":"83","author":"European Association for the Study of the Liver","year":"2025","journal-title":"Journal of Hepatology"},{"issue":"4","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/gastro\/goaa081","article-title":"Renal\u2010Function Change After Transjugular Intra\u2010Hepatic Portosystemic Shunt Placement and Its Relationship With Survival: A Single\u2010Center Experience","volume":"9","author":"Lang M.","year":"2020","journal-title":"Gastroenterology Report"},{"issue":"9","key":"e_1_2_12_11_1","first-page":"780","article-title":"Effects of Transjugular Intrahepatic Portosystemic Shunt on Renal and Pulmonary Function in Hepatic Decompensation With and Without Hepatorenal and Hepatopulmonary Syndromes: A Review","volume":"12","author":"Abdelwahed A. H.","year":"2024","journal-title":"Journal of Clinical and Translational Hepatology"},{"issue":"8","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.dld.2021.09.008","article-title":"Transjugular Intrahepatic Porto\u2010Systemic Shunt in Cirrhotic Patients With Hepatorenal Syndrome \u2010 Chronic Kidney Disease: Impact on Renal Function","volume":"54","author":"Ponzo P.","year":"2022","journal-title":"Digestive and Liver Disease"},{"issue":"3","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1053\/j.ajkd.2016.02.041","article-title":"Changes in Kidney Function After Transjugular Intrahepatic Portosystemic Shunts Versus Large\u2010Volume Paracentesis in Cirrhosis: A Matched Cohort Analysis","volume":"68","author":"Allegretti A. S.","year":"2016","journal-title":"American Journal of Kidney Diseases"},{"issue":"3","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/lt.25949","article-title":"Nonalcoholic Fatty Liver Disease and Diabetes Mellitus Are Associated With Post\u2010Transjugular Intrahepatic Portosystemic Shunt Renal Dysfunction: An Advancing Liver Therapeutic Approaches Group Study","volume":"27","author":"Ge J.","year":"2021","journal-title":"Liver Transplantation"},{"issue":"9","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A New Equation to Estimate Glomerular Filtration Rate","volume":"150","author":"Levey A. S.","year":"2009","journal-title":"Annals of Internal Medicine"},{"issue":"11","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1007\/s10620-020-06136-2","article-title":"Inpatient Mortality Benefit With Transjugular Intrahepatic Portosystemic Shunt for Hospitalized Hepatorenal Syndrome Patients","volume":"65","author":"Charilaou P.","year":"2020","journal-title":"Digestive Diseases and Sciences"},{"issue":"8","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.cgh.2021.07.018","article-title":"North American Practice\u2010Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension","volume":"20","author":"Boike J. R.","year":"2022","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"3","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1477-2574.2009.00040.x","article-title":"Renal Haemodynamics and Function Following Partial Portal Decompression","volume":"11","author":"Ross S.","year":"2009","journal-title":"Official Journal of the International Hepato Pancreato Biliary Association"},{"issue":"11","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13301","article-title":"Hepatic Vein Pressure Predicts GFR in Cirrhotic Patients With Hemodynamic Kidney Dysfunction","volume":"5","author":"Desai N.","year":"2017","journal-title":"Physiological Reports"},{"issue":"7","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/apt.18503","article-title":"Early Dynamics of Portal Pressure Gradient After TIPS Insertion Predict Mortality","volume":"61","author":"Reuken P. A.","year":"2025","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"6","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1053\/j.gastro.2017.01.011","article-title":"Timing Affects Measurement of Portal Pressure Gradient After Placement of Transjugular Intrahepatic Portosystemic Shunts in Patients With Portal Hypertension","volume":"152","author":"Silva\u2010Junior G.","year":"2017","journal-title":"Gastroenterology"},{"issue":"1","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00270-021-03003-z","article-title":"Transjugular Portosystemic Stent Shunt: Impact of Right Atrial Pressure on Portal Venous Hemodynamics Within the First Week","volume":"45","author":"Pitton M. B.","year":"2022","journal-title":"Cardiovascular and Interventional Radiology"},{"issue":"3","key":"e_1_2_12_23_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvir.2025.107924","article-title":"Systematic Literature Review and Meta\u2010Analysis of the Cardiovascular Effects of Transjugular Intrahepatic Portosystemic Shunt Creation for Decompensated Liver Cirrhosis","volume":"37","author":"Badar W.","year":"2026","journal-title":"Journal of Vascular and Interventional Radiology"},{"issue":"11","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.14309\/ajg.0000000000000786","article-title":"Hyponatremia in Cirrhosis: An Update","volume":"115","author":"Alukal J. J.","year":"2020","journal-title":"American Journal of Gastroenterology"},{"issue":"3","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/hep.22418","article-title":"Hyponatremia in Cirrhosis: Pathogenesis, Clinical Significance, and Management","volume":"48","author":"Gin\u00e8s P.","year":"2008","journal-title":"Hepatology"},{"issue":"7","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1053\/j.gastro.2025.08.029","article-title":"AGA Clinical Practice Update on the Management of Ascites, Volume Overload, and Hyponatremia in Cirrhosis: Expert Review","volume":"169","author":"Orman E. S.","year":"2025","journal-title":"Gastroenterology"},{"issue":"2","key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cld.2022.01.001","article-title":"Hyponatremia in Cirrhosis","volume":"26","author":"Rondon\u2010Berrios H.","year":"2022","journal-title":"Clinics in Liver Disease"},{"issue":"2","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.21037\/jtd-23-1649","article-title":"Hepatic Hydrothorax","volume":"16","author":"Wilkins H.","year":"2024","journal-title":"Journal of Thoracic Disease"},{"issue":"4","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cld.2019.06.003","article-title":"Pulmonary Complications of Portal Hypertension","volume":"23","author":"Cartin\u2010Ceba R.","year":"2019","journal-title":"Clinics in Liver Disease"},{"issue":"4","key":"e_1_2_12_30_1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/HEP.0000000000000577","article-title":"Refractory Hepatic Hydrothorax Is Associated With Increased Mortality With Death Occurring at Lower MELD\u2010Na Compared to Cirrhosis and Refractory Ascites","volume":"79","author":"Chin A.","year":"2024","journal-title":"Hepatology"},{"issue":"1","key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/j.jhep.2021.01.025","article-title":"Sarcopenia and Frailty in Decompensated Cirrhosis","volume":"75","author":"Tandon P.","year":"2021","journal-title":"Journal of Hepatology"},{"issue":"2","key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jhep.2023.04.021","article-title":"EASL Clinical Practice Guidelines on Acute\u2010On\u2010Chronic Liver Failure","volume":"79","author":"European Association for the Study of the Liver","year":"2023","journal-title":"Journal of Hepatology"},{"issue":"5","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","DOI":"10.3390\/medicina61050821","article-title":"Sarcopenia and Frailty in Cirrhotic Patients: Evaluation of Prevalence and Risk Factors in a Single\u2010Centre Cohort Study","volume":"61","author":"Atay K.","year":"2025","journal-title":"Medicina"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.70268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/kjm2.70268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/kjm2.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:57:47Z","timestamp":1785322667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/kjm2.70268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":32,"alternative-id":["10.1002\/kjm2.70268"],"URL":"https:\/\/doi.org\/10.1002\/kjm2.70268","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70268"}}