{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:18:21Z","timestamp":1788445101547,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear. This study aimed to identify Disulfidptosis\u2010 and Ferroptosis\u2010Related Genes (DFRGs) associated with RA and construct a candidate diagnostic model. Blood transcriptomic data from 154 RA patients and 43 healthy controls were analyzed. Differentially expressed DFRGs were identified, and immune infiltration was assessed using single\u2010sample Gene Set Enrichment Analysis (ssGSEA). Feature genes were selected through correlation analysis and logistic regression, followed by construction of a diagnostic nomogram. External validation was performed using independent datasets. Potential regulatory miRNAs and therapeutic agents were predicted, and single\u2010cell eQTL\u2010based Mendelian randomization (MR) was used to evaluate genetic associations between core gene expression and RA risk. Eleven DFRGs were identified and were enriched in p53, mTOR, and immune\u2010related pathways. Five feature genes, DUOX1, DRD4, ATP6V1G2, ASNS, and CDKN1A, were used to establish a diagnostic model with favorable performance in the training cohort and external validation datasets. Five key miRNAs and 61 potential therapeutic agents were predicted. MR suggested that ASNS expression may be protective, whereas ATP6V1G2 expression may increase RA risk. These findings suggest that DFRGs\u2010related signatures may be involved in RA pathogenesis and immune dysregulation, although further in\u00a0vitro and in\u00a0vivo validation is required.<\/jats:p>","DOI":"10.1002\/kjm2.70287","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:57:27Z","timestamp":1788443847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disulfidptosis\u2010 and Ferroptosis\u2010Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1122-462X","authenticated-orcid":false,"given":"Ting\u2010Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Rheumatology and Immunology Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Center Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-2425","authenticated-orcid":false,"given":"Shi\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Center Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Ying","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai\u2010Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-4463","authenticated-orcid":false,"given":"Fan\u2010Xin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Center Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-9590","authenticated-orcid":false,"given":"Jian\u2010Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Dazhou Central Hospital  Dazhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5487-4529","authenticated-orcid":false,"given":"Lin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid Arthritis","volume":"388","author":"Smolen J. 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S.","year":"2003","journal-title":"Nature"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"Ferroptosis and Autoimmune Diseases","volume":"13","author":"Lai B.","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2022.955069","article-title":"Ferroptosis in Inflammatory Arthritis: A Promising Future","volume":"13","author":"Chang S.","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy","volume":"13","author":"Zhao T.","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin Cytoskeleton Vulnerability to Disulfide Stress Mediates Disulfidptosis","volume":"25","author":"Liu X.","year":"2023","journal-title":"Nature Cell Biology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1056\/NEJMoa2210054","article-title":"Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency","volume":"389","author":"Block J.","year":"2023","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_10_1","first-page":"31","article-title":"DOCK11 Deficiency in Patients With X\u2010Linked Actinopathy and Autoimmunity","volume":"141","author":"Boussard C.","year":"2023","journal-title":"Blood"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3390\/biom13030450","article-title":"Actin Bundles Dynamics and Architecture","volume":"13","author":"Rajan S.","year":"2023","journal-title":"Biomolecules"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gkq1184","article-title":"NCBI GEO: Archive for Functional Genomics Data Sets: 10\u2009Years on","volume":"39","author":"Barrett T.","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaa021","article-title":"FerrDb: A Manually Curated Resource for Regulators and Markers of Ferroptosis and Ferroptosis\u2010Disease Associations","volume":"2020","author":"Zhou N.","year":"2020","journal-title":"Database (Oxford)"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1145\/2775052.2661094","article-title":"Dynamic Page Sharing Optimization for the R Language","volume":"50","author":"Kotthaus H.","year":"2015","journal-title":"ACM SIGPLAN Notices"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/imt2.36","article-title":"Sangerbox: A Comprehensive, Interaction\u2010Friendly Clinical Bioinformatics Analysis Platform","volume":"1","author":"Shen W.","year":"2022","journal-title":"iMeta"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41435-023-00209-8","article-title":"Potential Diagnostic Biomarkers: 6 Cuproptosis\u2010 and Ferroptosis\u2010Related Genes Linking Immune Infiltration in Acute Myocardial Infarction","volume":"24","author":"Miao M.","year":"2023","journal-title":"Genes and Immunity"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/978-1-4939-6990-6_22","article-title":"Metabolomic Bioinformatic Analysis","volume":"1606","author":"Dailey A. 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L.","year":"2021","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"\u201cMendelian Randomization\u201d: Can Genetic Epidemiology Contribute to Understanding Environmental Determinants of Disease?","volume":"32","author":"Smith G. D.","year":"2003","journal-title":"International Journal of Epidemiology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"eabf3041","DOI":"10.1126\/science.abf3041","article-title":"Single\u2010Cell eQTL Mapping Identifies Cell Type\u2010Specific Genetic Control of Autoimmune Disease","volume":"376","author":"Yazar S.","year":"2022","journal-title":"Science (New York, N.Y.)"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1024\/0040-5930\/a001403","article-title":"Rheumatoid Arthritis","volume":"80","author":"Lehmann J.","year":"2022","journal-title":"Therapeutische Umschau. 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