{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:48:43Z","timestamp":1791805723275,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>High body mass index (BMI) has been identified as a significant risk factor for childhood asthma. Given the rising prevalence of childhood obesity, assessing the impact of high BMI on asthma burden trends is imperative. Utilizing Global Burden of Disease (GBD) data, we estimated age\u2010, sex\u2010, geography\u2010, and sociodemographic index (SDI)\u2010stratified asthma\u2010related deaths and disability\u2010adjusted life years (DALYs) attributable to high BMI in children (0\u201314\u2009years old) (1990\u20132021). Health inequality was assessed by integrating SDI with the slope index of inequality and the relative concentration index. Bayesian age\u2010period\u2010cohort analysis projected asthma burden trends from 2022 to 2035. From 1990 to 2021, global asthma mortality due to high BMI declined, while DALYs rose. Females had higher mortality rates, whereas males exhibited greater DALY burdens. Mortality burden correlated negatively with SDI, whereas DALYs correlated positively. Cross\u2010national inequality analyses revealed higher mortality burdens in low\u2010SDI countries and elevated DALY burdens in high\u2010SDI regions. Frontier analyses indicated greater mortality reduction potential in low\u2010and low \u2010 middle \u2010 SDI areas and higher DALY mitigation opportunities in high\u2010SDI settings. Projections suggest a continued decline in asthma mortality but a rising DALY trend from 2022 to 2035. These findings highlight persistent sex\u2010 and SDI\u2010related disparities and support targeted strategies to reduce the global burden of childhood asthma attributable to high BMI.<\/jats:p>","DOI":"10.1002\/kjm2.70298","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:21:33Z","timestamp":1791804093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in the Asthma Burden Attributable to High Body Mass Index in Children Across 204 Countries and Territories, 1990\u20132021: An Analysis of the 2021 Global Burden of Disease Study"],"prefix":"10.1002","author":[{"given":"Hua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics Mianyang Maternal and Child Health Hospital  Mianyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mianyang Maternal and Child Health Hospital  Mianyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Zhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mianyang Maternal and Child Health Hospital  Mianyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mianyang Maternal and Child Health Hospital  Mianyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1020-3686","authenticated-orcid":false,"given":"Jia\u2010Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Mianyang Maternal and Child Health Hospital  Mianyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"StatPearls [Internet]","author":"Goldin J.","year":"2024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-025-03518-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.12.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2020.1825732"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2023.04.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00933-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.823399","article-title":"The Burden of Childhood Asthma by Age Group, 1990\u20102019: A Systematic Analysis of Global Burden of Disease 2019 Data","volume":"10","author":"Zhang D.","year":"2022","journal-title":"Frontiers in Pediatrics"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14366"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00397-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283624"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00367-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02475-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2012.00064.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102873"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30360-2"},{"issue":"8","key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.medj.2024.04.009","article-title":"Global Pattern, Trend, and Cross\u2010Country Inequality of Early Musculoskeletal Disorders From 1990 to 2019, With Projection From 2020 to 2050","volume":"5","author":"Collaborators GMiA","year":"2024","journal-title":"Medicine"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.04.011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.202200046"},{"key":"e_1_2_8_21_1","article-title":"Healthcare and Healthcare Systems: Inspiring Progress and Future Prospects","volume":"2","author":"Durrani H.","year":"2016","journal-title":"mHealth"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01605-2016"},{"issue":"6","key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s40272-023-00589-4","article-title":"Developments in the Management of Severe Asthma in Children and Adolescents: Focus on Dupilumab and Tezepelumab","volume":"25","author":"Dijk Y. 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