{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:49:34Z","timestamp":1792126174581,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mesenchymal stem cells (MSCs) have been shown to enhance tissue regeneration and wound healing. This preclinical study investigated the therapeutic potential of human bone marrow\u2010derived mesenchymal stem cells (hBM\u2010MSCs) for accelerating diabetic wound healing. Isolated hBM\u2010MSCs were characterized for surface marker expression and differentiation potential. Their migration\u2010promoting effects were evaluated in\u00a0vitro. For the in\u00a0vivo study, a dorsal skin defect model was created in streptozotocin (STZ)\u2010induced diabetic rats. Rats received periwound subcutaneous injections of low\u2010 or high\u2010dose hBM\u2010MSCs on Days 4 and 7, or freezing fluid as a vehicle control. Wound healing progression was assessed clinically, and tissue biopsies were analyzed using immunohistochemistry to evaluate inflammatory cell infiltration, cellular proliferation, and angiogenesis. hBM\u2010MSCs exhibited the expected surface marker profile and multilineage differentiation potential. In\u00a0vitro, hBM\u2010MSCs significantly enhanced the migration of human umbilical vein endothelial cells and human foreskin fibroblasts. In\u00a0vivo, wounds treated with hBM\u2010MSCs showed significantly accelerated healing compared to vehicle\u2010treated controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Immunohistochemical analysis revealed reduced inflammatory cell infiltration and increased expression of Ki\u201067, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and prolyl 4\u2010hydroxylase (P4H) in hBM\u2010MSC\u2010treated wounds. Allogeneic hBM\u2010MSCs significantly promote diabetic wound healing by suppressing inflammation, enhancing cellular proliferation and differentiation, and stimulating angiogenesis. These findings highlight the therapeutic potential of allogeneic hBM\u2010MSCs for treating diabetic wounds, particularly in patients unsuitable for autologous cell therapy.\n                  <\/jats:p>","DOI":"10.1002\/kjm2.70303","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:41:01Z","timestamp":1792125661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allogeneic Human Bone Marrow\u2010Derived Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Inflammation Suppression and Angiogenesis Promotion: A Preclinical Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-5390","authenticated-orcid":false,"given":"Rong\u2010Fu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Faculty of Medicine, College of Medicine, Orthopedic Research Center, Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng\u2010Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9422-8672","authenticated-orcid":false,"given":"Chia\u2010Chun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0057-3503","authenticated-orcid":false,"given":"Yu\u2010Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Hsin","family":"Shen","sequence":"additional","affiliation":[{"name":"Biomedical Technology and Device Research Laboratories Industrial Technology Research Institute  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-5009","authenticated-orcid":false,"given":"Yur\u2010Ren","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Faculty of Medicine, College of Medicine, Orthopedic Research Center, Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Biological Sciences National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"Academic Clinical Programme for Musculoskeletal Sciences Duke\u2010NUS Graduate Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","article-title":"Global Epidemiology of Diabetic Foot Ulceration: A Systematic Review and Meta\u2010Analysis","volume":"49","author":"Zhang P.","year":"2017","journal-title":"Annals of Medicine"},{"key":"e_1_2_8_3_1","first-page":"6901983","article-title":"Mesenchymal Stromal Cells and Cutaneous Wound Healing: A Comprehensive Review of the Background, Role, and Therapeutic Potential","volume":"2018","author":"Hu M. S.","year":"2018","journal-title":"Stem Cells International"},{"issue":"1","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00403-023-02783-3","article-title":"The Effects of Mesenchymal Stromal Cells and Platelet\u2010Rich Plasma Treatments on Cutaneous Wound Healing: Ignoring the Possibility of Adverse Events and Side Effects Could Compromise Study Results","volume":"316","author":"Klabukov I.","year":"2023","journal-title":"Archives of Dermatological Research"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"655","article-title":"Mesenchymal Stromal Cells Derived Exosomes as Tools for Chronic Wound Healing Therapy","volume":"59","author":"Rosca A. M.","year":"2018","journal-title":"Romanian Journal of Morphology and Embryology"},{"issue":"2","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.advms.2023.10.006","article-title":"Combination Therapy Along With Mesenchymal Stem Cells in Wound Healing; the State of the Art","volume":"68","author":"Daneste H.","year":"2023","journal-title":"Advances in Medical Sciences"},{"issue":"6","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/ten.teb.2019.0351","article-title":"Mesenchymal Stem Cells for Chronic Wound Healing: Current Status of Preclinical and Clinical Studies","volume":"26","author":"Huang Y. Z.","year":"2020","journal-title":"Tissue Engineering. Part B, Reviews"},{"issue":"9","key":"e_1_2_8_8_1","first-page":"2085","article-title":"Stem Cell\u2010Based Therapeutic Strategies in Diabetic Wound Healing","volume":"10","author":"Hsieh M. 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