{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:21:17Z","timestamp":1784082077193,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Medial open\u2010wedge high tibial osteotomy (OWHTO) is related to cartilage improvement in the medial compartment. This study aimed to evaluate factors associated with cartilage improvement and patient\u2010reported outcomes (PRO) after OWHTO. It was hypothesised that cartilage improvement is associated with favourable PRO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 94 patients who underwent OWHTO. The mean follow\u2010up period was 5 years. The weight\u2010bearing line ratio (WBLR) was defined as the ratio of the distance from the medial tibial edge to the tibial insertion of the weight\u2010bearing line and the tibial width. The International Cartilage Research Society grade evaluated the medial femoral condyle (MFC) and medial tibial plateau (MTP) at initial and second\u2010look arthroscopy, and cartilage improvement after OWHTO was assessed. Postoperative knee injury and osteoarthritis outcome scores (KOOS) were compared between the groups with improved and non\u2010improved cartilage. Additionally, factors related to cartilage improvement and postoperative KOOS scores were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding the MFC, KOOS pain, symptoms, activities of daily living (ADL)\u00a0and quality of life (QOL) were significantly higher in the cartilage\u2010improved group than in the non\u2010improved group (<jats:italic>p<\/jats:italic>\u2009=\u20090.012, 0.003, 0.001, 0.006), and cartilage improvement was significantly related to KOOS pain, ADL\u00a0and QOL (<jats:italic>p<\/jats:italic>\u2009=\u20090.021, 0.039, 0.013). In addition, the postoperative WBLR was associated with cartilage improvement, with a cutoff value of 54.0% (<jats:italic>p<\/jats:italic>\u2009=\u20090.046). Regarding the MTP, KOOS ADL\u00a0and QOL (<jats:italic>p<\/jats:italic>\u2009=\u20090.026, 0.022) were significantly higher in the cartilage\u2010improved group than in the nonimproved group. Body mass index (BMI) was significantly related to the postoperative QOL (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) and associated with cartilage improvement, with a cutoff value of 25.9\u2009kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A postoperative WBLR greater than 54.0% and a preoperative BMI below 25.9\u2009kg\/m<jats:sup>2<\/jats:sup> were associated with cartilage improvement, positively impacting PRO after OWHTO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level III, retrospective comparative study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ksa.12091","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T03:25:12Z","timestamp":1709004312000},"page":"725-735","source":"Crossref","is-referenced-by-count":10,"title":["Cartilage regeneration is related to superior mid\u2010term patient\u2010reported outcomes after open\u2010wedge high tibial osteotomy"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7093-2167","authenticated-orcid":false,"given":"Takahiro","family":"Tsushima","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Hirosaki University, Graduate School of Medicine Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4859-8473","authenticated-orcid":false,"given":"Eiji","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hirosaki University, Graduate School of Medicine Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hirosaki University, Graduate School of Medicine Hirosaki 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