{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:23:09Z","timestamp":1763749389322,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate 5\u2010year postoperative clinical outcomes of autologous matrix\u2010induced chondrogenesis (AMIC) for isolated ICRS grade 3\u20134 patellar cartilage defects and correlate outcomes with magnetic resonance imaging (MRI). The hypothesis was that AMIC would improve clinical symptoms and induce neocartilage formation, visible on MRI, making it a safe and effective option for repairing focal patellar cartilage defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 13 focal patellar lesions in 12 patients. Pain visual analogue scale (VAS), Knee Injury and Osteoarthritis Outcome Score (KOOS), Kujala score, EuroQol\u20105D Health Survey questionnaire and MRI data were assessed preoperatively and at 2 and 5 years postoperatively. All MRI scans were evaluated using the Magnetic Resonance Observation of Cartilage Repair Tissue System. Descriptive statistics were calculated on all data. Inferential analysis comparing outcome scores before and after surgery employed the nonparametric Wilcoxon signed\u2010rank test, with the nonparametric Friedman test used to detect differences across multiple test attempts.\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve patients (23\u201352 years old) with patellofemoral chondral full\u2010thickness defects (2\u20134\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ) were treated. At a 5\u2010year follow\u2010up, eleven knees showed MRI improvement. Two were asymptomatic and nine showed clear clinical improvement. Only one knee showed no clinical improvement. MRI revealed a defect filling with newly formed cartilage characterized by a less compact and heterogeneous signal. Cartilage degradation or joint damage was observed in two knees, and bone formation within the plate was identified in four. AMIC significantly improved patients' VAS pain, KOOS, EuroQol\u20105D and Kujala scores compared to preoperative baseline for up to 5 years postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Satisfactory clinical outcomes and new cartilage formation, as observed by MRI, are achieved with AMIC at mid\u2010term follow\u2010up for ICRS grade 3\u20134 in small\u2010to\u2010medium\u2010sized patellar defects in patients under 52 years of age, with improvements maintained for up to 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ksa.12518","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T14:26:22Z","timestamp":1730125582000},"page":"2104-2113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["AMIC achieves sustained clinical improvement in isolated patellar cartilage defects over 5 years, correlating with MRI"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8525-4485","authenticated-orcid":false,"given":"Nayana","family":"Joshi Jubert","sequence":"first","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona Departament de Cirurgia Bellaterra Spain"},{"name":"Hospital Universitari Vall d'Hebron, Departament de Cirurgia Ortop\u00e8dica i Traumatologia, Unitat de Genoll Barcelona Spain"},{"name":"Vall d'Hebron Institut de Recerca, Musculoskeletal Tissue Engineering group Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8 Revert\u00e9","family":"Vinaixa","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona Departament de Cirurgia Bellaterra Spain"},{"name":"Hospital Universitari Vall d'Hebron, Departament de Cirurgia Ortop\u00e8dica i Traumatologia, Unitat de Genoll Barcelona Spain"},{"name":"Vall d'Hebron Institut de Recerca, Musculoskeletal Tissue Engineering group Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene Portas","family":"Torres","sequence":"additional","affiliation":[{"name":"Vall d'Hebron Institut de Recerca, Musculoskeletal Tissue Engineering group Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-8715","authenticated-orcid":false,"given":"Daniel","family":"Moreno Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Institut de Diagn\u00f2stic per la Imatge Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Casaccia","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona Departament de Cirurgia Bellaterra Spain"},{"name":"Hospital Universitari Vall d'Hebron, Departament de Cirurgia Ortop\u00e8dica i Traumatologia, Unitat de Genoll Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Aguilar","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona Departament de Cirurgia Bellaterra Spain"},{"name":"Hospital Universitari Vall d'Hebron, Departament de Cirurgia Ortop\u00e8dica i Traumatologia, Unitat de Genoll Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan Pijoan","family":"Bueno","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona Departament de Cirurgia Bellaterra Spain"},{"name":"Hospital Universitari Vall d'Hebron, Departament de Cirurgia Ortop\u00e8dica i Traumatologia, Unitat de Genoll Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric Castellet","family":"Feliu","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona Departament de Cirurgia Bellaterra Spain"},{"name":"Hospital Universitari Vall d'Hebron, Departament de Cirurgia Ortop\u00e8dica i Traumatologia, Unitat de Genoll Barcelona Spain"},{"name":"Vall d'Hebron Institut de Recerca, Musculoskeletal Tissue Engineering group Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan Minguell","family":"Monyart","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona Departament de Cirurgia Bellaterra Spain"},{"name":"Hospital Universitari Vall d'Hebron, Departament de Cirurgia Ortop\u00e8dica i Traumatologia, Unitat de Genoll Barcelona Spain"},{"name":"Vall d'Hebron Institut de Recerca, Musculoskeletal Tissue Engineering group Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519893076"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbo.2017.06.019"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12354"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"260","article-title":"Autologous matrix\u2010induced chondrogenesis (AMIC). A one\u2010step procedure for retropatellar articular resurfacing","volume":"76","author":"Benthien J.P.","year":"2010","journal-title":"Acta Orthopaedica Belgica"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-15-00447"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030392"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512473258"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"251","article-title":"Treatment of patellofemoral cartilage defects in the knee by autologous matrix\u2010induced chondrogenesis (AMIC)","volume":"80","author":"Dhollander A.","year":"2014","journal-title":"Acta Orthopaedica Belgica"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515574063"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119868212"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517740575"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06923-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519845362"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2309499019851011"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519886853"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jisako.2022.11.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12206434"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2024.08.003"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512441585"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-020-03564-7"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-021-06513-y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967120959280"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03419-4"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X15666200221122834"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11020141"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02684-z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-022-02155-y"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2023.103774"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1657-z"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/230949901302100104"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519865308"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-5139-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519841673"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519870846"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041184"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR-23-0089"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-024-03948-0"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035211021908"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2007.02.001"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.12518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:40:50Z","timestamp":1761140450000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/ksa.12518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/ksa.12518"],"URL":"https:\/\/doi.org\/10.1002\/ksa.12518","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"type":"print","value":"0942-2056"},{"type":"electronic","value":"1433-7347"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}