{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:41:54Z","timestamp":1789576914608,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The INtensive diet versus Knee Arthroplasty (INKA) trial is a randomised trial assessing weight loss as an alternative to knee arthroplasty (KA) in obese patients with severe knee osteoarthritis (OA) awaiting KA (NCT05172843). The external validity of the INKA trial may be hampered if the patients who participate differ from those who decline participation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare baseline characteristics between patients who enrol in the INKA trial and those who decline participation (i.e., non\u2010INKA [nINKA] group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied a cross\u2010sectional study design, collecting and comparing baseline characteristics among all patients eligible for enrolment in the INKA trial from two clinics in Copenhagen. Imbalance between accepting (INKA) and declining (nINKA) groups was assessed using standardised differences (StdDs). We were prespecified that StdD values\u2009&lt;\u20090.20 would indicate a clinically insignificant imbalance between groups, whereas values\u2009&gt;\u20090.80 indicate incomparability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 913 patients scheduled for KA, 888 were screened for INKA trial eligibility. Of the 217 eligible patients, 92 (42%) were enroled in the INKA trial, while 37 (17%) participated in the nINKA cross\u2010sectional sample only. Patients enroled in INKA had on average a less severe Oxford knee score (OKS) of 22.0 (standard deviation\u2009=\u20096.7) compared to declining participants in nINKA with 18.6 (7.2), corresponding to an StdD of 0.50, and an absolute difference of 3.45 (95% confidence interval\u2009=\u20090.64\u20136.26, <jats:italic>p<\/jats:italic>\u2009=\u20090.017). A consistent similar pattern was noted across all secondary patient\u2010reported outcomes applied in the INKA trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed discrepancies in patient\u2010reported outcomes, with those who declined enrolment reporting more severe symptoms. These differences, however, were below the minimally important difference between groups for OKS, which is set to 4.84 points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level II\u2013III cross\u2010sectional study in a randomised control trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ksa.12546","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T11:54:26Z","timestamp":1736078066000},"page":"3070-3079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of eligible patients with knee osteoarthritis accepting versus declining participation in a randomised trial investigating the effect of weight loss versus knee arthroplasty to explore generalisability: A cross\u2010sectional study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-995X","authenticated-orcid":false,"given":"Saber Muthanna","family":"Aljuboori","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Traumatology Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Copenhagen Denmark"},{"name":"The Parker Institute Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Frederiksberg Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-0631","authenticated-orcid":false,"given":"Robin","family":"Christensen","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Frederiksberg Denmark"},{"name":"Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-2962","authenticated-orcid":false,"given":"Marius","family":"Henriksen","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Frederiksberg Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-1668","authenticated-orcid":false,"given":"Henning","family":"Bliddal","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Frederiksberg Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-8182","authenticated-orcid":false,"given":"Anders","family":"Troelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Orthopedic Surgery Copenhagen University Hospital\u2014Hvidovre &amp; Amager Hivdovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-6563","authenticated-orcid":false,"given":"Mikael","family":"Boesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Radiology Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6976-9868","authenticated-orcid":false,"given":"Asbj\u00f8rn Seenithamby","family":"Poulsen","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Frederiksberg Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-8730","authenticated-orcid":false,"given":"Camilla Toft","family":"Nielsen","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Frederiksberg Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Radiology Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-7610","authenticated-orcid":false,"given":"Kristine Ifigenia","family":"Bunyoz","sequence":"additional","affiliation":[{"name":"The Parker Institute Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Frederiksberg Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Orthopedic Surgery Copenhagen University Hospital\u2014Hvidovre &amp; Amager Hivdovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-4787","authenticated-orcid":false,"given":"S\u00f8ren","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Traumatology Copenhagen University Hospital\u2014Bispebjerg &amp; Frederiksberg Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.08.014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.09.007"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.08.009"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903018911"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-399"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.04.008"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00628"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.158543"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.065904"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22504"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/17453674.2023.11656"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.03.010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174053"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00016"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78665-0_5"},{"issue":"10","key":"e_1_2_12_19_1","article-title":"Factors that impact on recruitment to randomised trials in health care: a qualitative evidence synthesis","volume":"2020","author":"Houghton C.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00832-3"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-1023-4"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1457496919883812"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-36162011000400018"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2016.05.007"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870440290001494"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-64"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17670-8"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.12.016"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(23)00337-5"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181194"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2390"},{"key":"e_1_2_12_32_1","unstructured":"Overview. Osteoarthritis: care and management. Guidance. NICE.https:\/\/www.nice.org.uk\/guidance\/CG177"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.12546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:07:56Z","timestamp":1760875676000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/ksa.12546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,5]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ksa.12546"],"URL":"https:\/\/doi.org\/10.1002\/ksa.12546","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,5]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}