{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:35:47Z","timestamp":1792524947017,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Medial opening wedge high tibial osteotomy (MOWHTO) is a reliable joint\u2010preserving surgical procedure for isolated medial compartment knee osteoarthritis (OA) and overload. The aim of this study was to evaluate the long\u2010term survivorship and clinical outcomes of patients undergoing MOWHTO and to identify the risk factors associated with an increased risk of failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of prospectively collected patients who underwent MOWHTO for isolated medial OA and overload between 2002 and 2023. Clinical outcomes were evaluated using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Tegner activity score. Radiographic analysis included hip\u2013knee\u2013ankle (HKA) angle and medial proximal tibial angle (MPTA). Survivorship was intended from conversion to total knee arthroplasty (TKA). Logistic regression was used to identify risk factors, and <jats:italic>p<\/jats:italic> values\u2009&lt;\u20090.05 were considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred thirty\u2010one patients who underwent MOWHTO were included for analysis. Males were 82.5%, and the mean age was 49.1\u2009\u00b1\u20098.0 years. The KOOS increased in any subsection at mean 5.7\u2009\u00b1\u20094.5 years of follow\u2010up (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Complication rate was 35.9% and reoperation rate was 25.5% at mean 9.6 years of follow\u2010up. Removal of metal hardware due to pain and\/or discomfort was the main cause of reoperation in 22% of the patients. The cumulative rate of conversion to TKA at 5 years was 2.2%, at 10 years 17.8% and at 15 years 37.1%. Age (odds ratio [OR]: 1.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.017), wedge thickness (OR: 1.08, <jats:italic>p<\/jats:italic>\u2009=\u20090.015), medial femoral condyle OA (OR: 3.41, <jats:italic>p<\/jats:italic>\u2009=\u20090.029), medial tibial plateau OA (OR: 2.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.044), post\u2010operative HKA (OR: 1.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) and post\u2010operative MPTA (OR: 1.26, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) were associated with an increased risk of failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MOWHTO yields satisfactory 10\u2010year survivorship in patients with medial compartment isolated knee OA and overload. Age, preoperative stage of OA, cartilage wear and post\u2010operative alignment are relevant patient\u2010related risk factors for reduced survivorship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level III, retrospective cohort study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ksa.12633","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T06:11:26Z","timestamp":1740031886000},"page":"1804-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Satisfactory 10\u2010year survivorship of medial opening wedge high tibial osteotomy for isolated medial compartment osteoarthritis and varus alignment: An analysis from a high\u2010volume institution"],"prefix":"10.1002","volume":"33","author":[{"given":"Cristian A. Brito","family":"Ayet","sequence":"first","affiliation":[{"name":"Sydney Orthopaedic Research Insitute (SORI), The Knee Institute Landmark Orthopaedics Sydney New South Wales Australia"},{"name":"Chilean Navi Hospital Vina del Mar Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-0052","authenticated-orcid":false,"given":"Fabio","family":"Mancino","sequence":"additional","affiliation":[{"name":"Sydney Orthopaedic Research Insitute (SORI), The Knee Institute Landmark Orthopaedics Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoong P.","family":"Lim","sequence":"additional","affiliation":[{"name":"Sydney Orthopaedic Research Insitute (SORI), The Knee Institute Landmark Orthopaedics Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Qian","sequence":"additional","affiliation":[{"name":"University of Newcastle Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Jacob","sequence":"additional","affiliation":[{"name":"Sydney Orthopaedic Research Insitute (SORI), The Knee Institute Landmark Orthopaedics Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Parker","sequence":"additional","affiliation":[{"name":"Sydney Orthopaedic Research Insitute (SORI), The Knee Institute Landmark Orthopaedics Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2016.06.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1616-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-008-1234-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30059-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513516577"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2020.08.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-022-07122-z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)30753-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12469"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-008-0569-y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.13674"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.11.009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12119"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198769030-00005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510397535"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510377445"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.08.040"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12041"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2018.11.008"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211059162"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-016-4732-4"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12252"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-021-03769-4"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671231213595"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12096"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12317"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-021-03927-8"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-06262-4"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12273"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.200934"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211059811"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-010-1102-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-009-0757-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2859-7"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2011.01.008"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-012-2114-3"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518758016"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12435"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515624925"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671221136501"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1751-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-014-3433-3"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-018-2199-6"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2015.09.018"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.12633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:22:37Z","timestamp":1760869357000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/ksa.12633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/ksa.12633"],"URL":"https:\/\/doi.org\/10.1002\/ksa.12633","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]},"assertion":[{"value":"2024-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}