{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:48:00Z","timestamp":1790657280582,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increasing interest in biologic treatments for musculoskeletal disorders has led to the advancement of orthobiologics, particularly in non\u2010operative care through injectable therapies. However, defining these treatments clearly is crucial for proper clinical application. Orthobiologics include biologic substances that enhance healing, such as cell\u2010based therapies and blood\u2010derived products. Among these, platelet\u2010rich plasma (PRP) is widely used, but its classification remains complex due to variations in preparation methods, platelet concentration, leucocyte content, and activation techniques. Strictly, the term \u2018PRP\u2019 refers to plasma enriched in platelets relative to baseline blood levels. Yet, scientific debate persists regarding whether platelet count or enrichment is more significant in clinical outcomes. Additionally, leucocyte\u2010rich and leucocyte\u2010poor PRPs offer different therapeutic advantages depending on the target tissue, complicating standardization. Similarly, the presence of red blood cells is generally discouraged, given their association with joint inflammation. Beyond the classical \u2018PRP\u2019 formulations, alternative blood\u2010derived products offer distinct biological effects. A standardized classification system is therefore essential for research and clinical application, emphasizing precise documentation of products' characteristics, including platelet count, activation state and bioactive molecule interactions. Understanding these variables and their impact on patient\u2010specific conditions will refine orthopaedic regenerative strategies and optimize treatment efficacy.<\/jats:p>","DOI":"10.1002\/ksa.12655","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T06:44:40Z","timestamp":1741848280000},"page":"1920-1924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["PRP or not PRP: Is the debate surrounding platelets\u2010based blood\u2010derived products evolving?"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-7417","authenticated-orcid":false,"given":"Enrico","family":"Ragni","sequence":"first","affiliation":[{"name":"IRCCS Ospedale Galeazzi \u2013 Sant'Ambrogio Laboratorio di Biotecnologie Applicate all'Ortopedia Milano 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