{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:01:57Z","timestamp":1785765717193,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate factors associated with 10\u2010year clinical scores after matrix\u2010induced autologous chondrocyte implantation (MACI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case series included 143 MACI patients with 10\u2010year clinical and radiological follow\u2010up. Clinical assessment included the Knee Injury and Osteoarthritis Outcome Score (KOOS) quality of life (KOOS\u2010QOL) and sport and recreation (KOOS\u2010Sport\/Rec) subscales, and patient satisfaction. Regression analysis investigated the contribution of patient (age, sex, body mass index and preoperative physical health), surgical (symptom duration, prior surgeries, defect size and location) and postoperative variables, such as knee extensor strength and a magnetic resonance imaging (MRI) composite graft score, to 10\u2010year clinical scores and being \u2018very satisfied\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The KOOS\u2010QOL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and KOOS\u2010Sport\/Rec (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) improved from baseline to 10 years, with 88 (61.5%) patients \u2018very satisfied\u2019 with their outcome. A lower number of prior surgical procedures, greater knee extensor strength, and a better 10\u2010year MRI score contributed significantly to a higher KOOS\u2010QOL. For the KOOS\u2010Sport\/Rec, a lower number of prior surgical procedures, undergoing tibiofemoral (versus patellofemoral) MACI, greater preoperative physical health and a better 10\u2010year MRI score contributed significantly to a better score. Finally, a lower number of prior procedures and greater preoperative physical health contributed to a patient being \u2018very satisfied\u2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Factors including the number of prior procedures, defect location, preoperative physical health, postoperative quadriceps strength and MRI\u2010based graft integrity were associated with improved 10\u2010year clinical scores. This information will permit more tailored patient discussion, along with the setting of realistic, longer\u2010term expectations for outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ksa.12699","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:50:43Z","timestamp":1751878243000},"page":"509-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prior procedures, graft location, preoperative physical health, postoperative strength and graft integrity are associated with 10\u2010year clinical outcome after matrix\u2010induced autologous chondrocyte implantation"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-6243","authenticated-orcid":false,"given":"Jay R.","family":"Ebert","sequence":"first","affiliation":[{"name":"School of Human Sciences (Exercise and Sport Science) University of Western Australia Perth Western Australia Australia"},{"name":"HFRC Rehabilitation Clinic Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Edwards","sequence":"additional","affiliation":[{"name":"School of Allied Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Klinken","sequence":"additional","affiliation":[{"name":"Perth Radiological Clinic Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Wood","sequence":"additional","affiliation":[{"name":"School of Surgery (Orthopaedics) University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-2951","authenticated-orcid":false,"given":"Gregory C.","family":"Janes","sequence":"additional","affiliation":[{"name":"Perth Orthopaedic &amp; Sports Medicine Centre Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514548160"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2022.08.041"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.02.012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509350555"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518756976"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300002-00008"},{"key":"e_1_2_12_8_1","first-page":"181","article-title":"Surgical management of articular cartilage defects in the knee","volume":"59","author":"Cole BJ","year":"2010","journal-title":"Instr Course Lect"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-022-07030-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603516650002"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519886548"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510380902"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520980109"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516663493"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512445167"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.26603\/ijspt20200001"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510390476"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513484696"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514534942"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119885873"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241227969"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2014.5055"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-010-0939-8"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603516638901"},{"key":"e_1_2_12_25_1","volume-title":"Applied survival analysis: regression modeling of time to event data","author":"Hosmer D","year":"1999"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12661"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.08.007"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2004.03.014"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509332258"},{"key":"e_1_2_12_30_1","article-title":"Autologous chondrocyte implantation, matrix\u2010induced autologous chondrocyte implantation, osteochondral autograft transplantation and osteochondral allograft improve knee function and pain with considerations for patient and cartilage defects characteristics: a systematic review and meta\u2010analysis","author":"Nassar JE","year":"2024","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.03.009"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2006.11.009"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510391084"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-64"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.2.88"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-19-00151"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2018.01.021"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12433"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.08.006"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035221147680"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517741465"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967117753572"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12359"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241270152"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509354971"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514554910"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.12699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ksa.12699","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.12699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:20:02Z","timestamp":1773015602000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/ksa.12699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ksa.12699"],"URL":"https:\/\/doi.org\/10.1002\/ksa.12699","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}