{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:53:57Z","timestamp":1781520837504,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Total knee arthroplasty (TKA) alignment strategies affect lower limb biomechanics during functional activities. This study assessed sit\u2010to\u2010stand performance between individuals who underwent TKA with inverse kinematic alignment (iKA), adjusted mechanical alignment (aMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The iKA and aMA groups were compared to a healthy control group in their performance of the five times sit\u2010to\u2010stand (5xSTS) task. Phase\u2010specific timing and joint angles were analysed using statistical parametric mapping (SPM) and conventional metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included a 2\u2010year follow\u2010up after TKA, with a minimum follow\u2010up of 21.50\u2009\u00b1\u20095.20 months. Each group had 15 participants. The iKA group (72.52\u2009\u00b1\u20095.50 years) was older than the aMA group (66.10\u2009\u00b1\u20098.22 years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). The aMA group demonstrated a significantly shorter sit\u2010down phase compared to healthy controls (9.48\u2009\u00b1\u20090.72% vs. 10.80\u2009\u00b1\u20091.33%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Additionally, the aMA group (15.92\u2009\u00b1\u20097.47\u00b0) exhibited approximately 7\u00b0 less ankle range of motion (ROM) during the stand\u2010up phase compared to both the iKA group (22.83\u2009\u00b1\u20096.90\u00b0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) and healthy controls (23.61\u2009\u00b1\u20096.76\u00b0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). During the sit\u2010down phase, the aMA group displayed a significantly reduced average ankle ROM (14.05\u2009\u00b1\u20097.89\u00b0) compared to healthy controls (19.73\u2009\u00b1\u20095.34\u00b0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). The SPM analysis revealed no significant differences in ankle or knee flexion angles across the groups during the entire 5xSTS task.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that the ankle ROM is influenced following TKA during the 5xSTS task, suggesting that alignment strategies may have biomechanical effects extending beyond the knee joint. A deeper understanding of these effects could inform rehabilitation strategies and optimise surgical outcomes following TKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ksa.70113","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:23:18Z","timestamp":1761682998000},"page":"2108-2120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preserving the native knee joint line obliquity in total knee arthroplasty benefits ankle movement during the five times sit\u2010to\u2010stand test"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-3321","authenticated-orcid":false,"given":"Zhijun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven Brugge Belgium"},{"name":"Department of Bioengineering Laboratory, Orthopaedic Surgery Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Winnock","family":"de Grave","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven Brugge Belgium"},{"name":"Department of Orthopaedic Surgery AZ Delta Roeselare Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaya Van","family":"Criekinge","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven Brugge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Luyckx","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven Brugge Belgium"},{"name":"Department of Orthopaedic Surgery AZ Delta Roeselare Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2794-3071","authenticated-orcid":false,"given":"Kurt","family":"Claeys","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences KU Leuven Brugge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"2007","article-title":"The Bonferonni and \u0160id\u00e1k corrections for multiple comparisons","volume":"3","author":"Abdi H","year":"2007","journal-title":"Encycl Meas 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