{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:42:18Z","timestamp":1792190538589,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To synthesise the paradigm shift towards precision medicine in orthopaedics, where individual anatomical, biomechanical, molecular and kinematic characteristics are integrated into clinical decision\u2010making. Unlike traditional approaches applying uniform protocols, this review outlines how precision orthopaedics aims to tailor surgical techniques, implant selection, component positioning and rehabilitation strategies to the unique profile of each patient, thereby improving outcomes and predictability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This narrative review synthesises current concepts and evidence supporting patient\u2010specific care. The methods discussed encompass a wide range of technological and biological innovations, including advanced imaging, robotic\u2010assisted surgery, artificial intelligence (AI), molecular diagnostics, functional assessment tools and personalised therapeutic platforms that are shaping modern orthopaedic practice across multiple subspecialties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total knee arthroplasty, personalised alignment restores native joint lines, while robotic systems execute plans with submillimetre accuracy, reducing alignment outliers and potentially improving functional outcomes. In total hip arthroplasty, spinopelvic analysis mitigates instability risk, a critical factor for patients with spinal stiffness. Intraoperative technologies like robotics, patient\u2010specific instruments and augmented reality improve the precision of implant placement and reduce radiation exposure in trauma. Beyond arthroplasty, AI accelerates early diagnosis of osteoarthritis, while molecular biomarkers (e.g., alpha\u2010defensin) offer &gt;95% accuracy in diagnosing periprosthetic joint infection. Finally, AI\u2010guided digital platforms and motion tracking are used to deliver personalised rehabilitation protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Precision medicine encompasses a wide range of powerful tools, many of which are already in clinical use. However, their full and effective integration requires continued research, long\u2010term validation, cost\u2010effectiveness analyses and interdisciplinary collaboration. The future of orthopaedics is anchored in delivering the right intervention for the right patient at the right time, guided by robust, individualised data and sound clinical judgement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level V.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ksa.70168","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T07:29:01Z","timestamp":1761982141000},"page":"633-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Precision medicine in orthopaedics: A review of current technologies and future directions"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-555X","authenticated-orcid":false,"given":"Patrick","family":"Sadoghi","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Trauma Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-4708","authenticated-orcid":false,"given":"Amir","family":"Koutp","sequence":"additional","affiliation":[{"name":"Alps Surgery Institute Clinique Generale Annecy Annecy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-0692","authenticated-orcid":false,"given":"Elmar","family":"Herbst","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-9623","authenticated-orcid":false,"given":"Giuseppe","family":"Milano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia Brescia Italy"},{"name":"Department of Bone and Joint Surgery ASST Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-6212","authenticated-orcid":false,"given":"Volker","family":"Musahl","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-424X","authenticated-orcid":false,"given":"Michael T.","family":"Hirschmann","sequence":"additional","affiliation":[{"name":"University Department of Orthopedic Surgery and Traumatology Kantonsspital Baselland Bruderholz Switzerland"},{"name":"Department of Clinical Research, Research Group Michael T. 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