{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:01:13Z","timestamp":1781881273388,"version":"3.54.5"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet\u2010rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard ACLR without biological additives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred seventy\u2010five patients undergoing biologically enhanced ACLR using semitendinosus quadruple autograft were prospectively included in this randomized controlled trial. Patients were randomized to either the control group (no biological additives,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200979) or ACLR plus application of PRP to the graft (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953) or ACLR plus BMAC application to the graft (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943). ACLR techniques were standardized for all patients, and all were performed by a senior surgeon. Biological additives were also standardized and prepared by a senior laboratory physician in the operating room. After an average of 2 years, patients were assessed clinically, and SI of the ACL graft was measured in the magnetic resonance imaging (MRI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no clinically significant difference in clinical outcomes (clinical examination [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.867] and patients' reported outcome scores, Lysholm [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.881], International Knee Documentation Committee [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.864] and Marx activity return to sport scale [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.666]). There was no significant difference in MRI SI of the intra\u2010articular graft or the graft inside the tunnels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.898) after a mean of 2 years. Cases with BMAC addition to the graft showed poorer MRI SI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biological ACL reconstruction enhanced with PRP or BMAC did not reveal any statistically significant clinical or radiological results; on the contrary, BMAC application may lead to poorer MRI SI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ksa.70484","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:46:36Z","timestamp":1781880396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biologically enhanced anterior cruciate ligament reconstruction: Platelet\u2010rich plasma or bone marrow aspirate concentrate does not lead to better clinical or radiological outcomes\u2014A randomized controlled trial of 175 cases with 2 years of follow\u2010up"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3454-8061","authenticated-orcid":false,"given":"Akram Aldawoudy","family":"Mokhtar","sequence":"first","affiliation":[{"name":"AlexKnee Center Alexandria Egypt"},{"name":"University Department of Orthopaedic Surgery and Traumatology Kantonsspital Baselland Bruderholz Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-6353","authenticated-orcid":false,"given":"Hesham","family":"Gawish","sequence":"additional","affiliation":[{"name":"Department Orthopedic Surgery and Traumatology, Faculty of Medicine Kafrelsheikh University Kafrelsheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdelgawad","sequence":"additional","affiliation":[{"name":"AlexKnee Center Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Deghady","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa","family":"Hassaan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Matarawy","sequence":"additional","affiliation":[{"name":"Radiology Department, Medical Research Institute Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Amer","sequence":"additional","affiliation":[{"name":"Radiology Department, Medical Research Institute Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiman","family":"Soliman","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Rheumatology and Clinical Immunology, Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Hirschmann","sequence":"additional","affiliation":[{"name":"University Department of Orthopaedic Surgery and Traumatology Kantonsspital Baselland Bruderholz Switzerland"},{"name":"Department of Clinical Research, Research Group Michael T. Hirschmann, Regenerative Medicine and Biomechanics University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"issue":"6","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1053\/j.jfas.2022.02.015","article-title":"Return to sports activities after flexor hallucis longus transfer for neglected Achilles tendon rupture","volume":"61","author":"Ahn J","year":"2022","journal-title":"J Foot Ankle Surg"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70031"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/371746","article-title":"PRP augmentation for ACL reconstruction","volume":"2015","author":"Andriolo L","year":"2015","journal-title":"BioMed Res Int"},{"issue":"21","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/bjsports-2013-093398","article-title":"Fifty\u2010five per cent return to competitive sport following anterior cruciate ligament reconstruction surgery: an updated systematic review and meta\u2010analysis including aspects of physical functioning and contextual factors","volume":"48","author":"Ardern CL","year":"2014","journal-title":"Br J Sports Med"},{"issue":"1","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","DOI":"10.1177\/2325967117750825","article-title":"Career length and injury incidence after anterior cruciate ligament reconstruction in major league soccer players","volume":"6","author":"Arundale AJH","year":"2018","journal-title":"Orthop J Sports Med"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/S0020-1383(14)70008-7","article-title":"Comparison between two different platelet\u2010rich plasma preparations and control applied during anterior cruciate ligament reconstruction. Is there any evidence to support their use?","volume":"45","author":"Azc\u00e1rate AV","year":"2014","journal-title":"Injury"},{"issue":"3","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/ksa.12747","article-title":"Lower body mass index, higher Beighton score, complete anterior cruciate ligament tear, concomitant injuries to medial collateral ligament, anterolateral complex and meniscus especially posterior horn are risk factors for preoperative high\u2010 grade pivot shift under anaesthesia of patients with anterior cruciate ligament injury: a systematic review and meta analysis","volume":"34","author":"Bai W","year":"2026","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"12","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1177\/03635465211036471","article-title":"Platelet\u2010rich plasma augmentation of meniscal repair in the setting of anterior cruciate ligament reconstruction","volume":"49","author":"Bailey L","year":"2021","journal-title":"Am J Sports Med"},{"issue":"3","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1177\/0363546514561435","article-title":"MRI volume and signal intensity of ACL graft predict clinical, functional, and patient\u2010oriented outcome measures after ACL reconstruction","volume":"43","author":"Biercevicz AM","year":"2015","journal-title":"Am J Sports Med"},{"issue":"3","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1177\/0363546512472978","article-title":"In situ, noninvasive, T2*\u2010weighted MRI\u2010derived parameters predict ex vivo structural properties of an anterior cruciate ligament reconstruction or bioenhanced primary repair in a porcine model","volume":"41","author":"Biercevicz AM","year":"2013","journal-title":"Am J Sports Med"},{"issue":"8","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1302\/2633-1462.28.BJO-2021-0104.R1","article-title":"Two\u2010year postoperative MRI appearances of anterior cruciate ligament hamstrings autografts are not correlated with functional outcomes, anterior laxity, or patient age","volume":"2","author":"Bouguennec N","year":"2021","journal-title":"Bone Joint Open"},{"issue":"9","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1177\/0363546512454414","article-title":"Survival of the anterior cruciate ligament graft and the contralateral ACL at a minimum of 15 years","volume":"40","author":"Bourke HE","year":"2012","journal-title":"Am J Sports Med"},{"issue":"10","key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1111\/os.13279","article-title":"Effectiveness of platelet\u2010rich plasma in anterior cruciate ligament reconstruction: a systematic review of randomized controlled trials","volume":"14","author":"Cao Y","year":"2022","journal-title":"Orthop Surg"},{"issue":"2","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1016\/j.eats.2016.10.024","article-title":"Bone marrow aspirate concentrate harvesting and processing technique","volume":"6","author":"Chahla J","year":"2017","journal-title":"Arthrosc Tech"},{"issue":"10","key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1007\/s00167-018-4910-x","article-title":"Graft bending angle affects allograft tendon maturity early after anterior cruciate ligament reconstruction","volume":"26","author":"Chen L","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"7","key":"e_1_2_13_17_1","doi-asserted-by":"crossref","DOI":"10.1177\/23259671221109608","article-title":"Association between early postoperative graft signal intensity and residual knee laxity after anterior cruciate ligament reconstruction","volume":"10","author":"Chiba D","year":"2022","journal-title":"Orthop J Sports Med"},{"issue":"8","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","DOI":"10.1177\/2325967119863056","article-title":"Quantitative MRI UTE\u2010T2* and T2* show progressive and continued graft maturation over 2 years in human patients after anterior cruciate ligament reconstruction","volume":"7","author":"Chu CR","year":"2019","journal-title":"Orthop J Sports Med"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70050"},{"issue":"11","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1177\/0363546511402662","article-title":"The \u201cligamentization\u201d process in anterior cruciate ligament reconstruction: what happens to the human graft? A systematic review of the literature","volume":"39","author":"Claes S","year":"2011","journal-title":"Am J Sports Med"},{"issue":"1","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.arthro.2004.09.015","article-title":"Variation in anterior cruciate ligament scar pattern: does the scar pattern affect anterior laxity in anterior cruciate ligament\u2010deficient knees?","volume":"21","author":"Crain EH","year":"2005","journal-title":"Arthroscopy"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70058"},{"issue":"5","key":"e_1_2_13_23_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s11547-025-01973-5","article-title":"Can MRI predict return to sport after anterior cruciate ligament reconstruction? A systematic review of the literature","volume":"130","author":"D'Ambrosi R","year":"2025","journal-title":"Radiol Med (Torino)"},{"issue":"5","key":"e_1_2_13_24_1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/ksa.12127","article-title":"Platelet\u2010rich plasma augmentation in anterior cruciate ligament reconstruction: Evidence is still too scattered. A scoping review of randomised controlled trials","volume":"32","author":"Delcogliano M","year":"2024","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70052"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70011"},{"issue":"5","key":"e_1_2_13_27_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.arthro.2014.11.022","article-title":"Platelet\u2010rich plasma use in anterior cruciate ligament surgery: systematic review of the literature","volume":"31","author":"Figueroa D","year":"2015","journal-title":"Arthroscopy"},{"issue":"10","key":"e_1_2_13_28_1","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1007\/s00167-011-1837-x","article-title":"Platelet\u2010rich plasma intra\u2010articular injections for cartilage degeneration and osteoarthritis: single versus double\u2010spinning approach","volume":"20","author":"Filardo G","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"7","key":"e_1_2_13_29_1","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.arthro.2022.01.010","article-title":"Bone marrow aspirate concentrate augmentation may accelerate allograft ligamentization in anterior cruciate ligament reconstruction: a double\u2010blinded randomized controlled trial","volume":"38","author":"Forsythe B","year":"2022","journal-title":"Arthroscopy"},{"issue":"4","key":"e_1_2_13_30_1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00167-013-2755-x","article-title":"Comparison of tendon\u2013bone healing between autografts and allografts after anterior cruciate ligament reconstruction using magnetic resonance imaging","volume":"23","author":"Ge Y","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"9","key":"e_1_2_13_31_1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1302\/0301-620X.89B9.19339","article-title":"Anterior cruciate ligament reconstruction using autologous double hamstrings: a comparison of standard versus minimal debridement techniques using MRI to assess revascularisation: a randomised prospective study with a one\u2010year follow\u2010up","volume":"89","author":"Gohil S","year":"2007","journal-title":"J Bone Joint Surg Br"},{"issue":"5","key":"e_1_2_13_32_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s43465-021-00533-z","article-title":"Clinical use of platelet\u2010rich plasma to promote tendon\u2013bone healing and graft maturation in anterior cruciate ligament reconstruction\u2014a randomized controlled study","volume":"56","author":"Gong H","year":"2022","journal-title":"Indian J Orthop"},{"issue":"10","key":"e_1_2_13_33_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.5312\/wjo.v7.i10.638","article-title":"Magnetic resonance imaging after anterior cruciate ligament reconstruction: a practical guide","volume":"7","author":"Grassi A","year":"2016","journal-title":"World J Orthop"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70069"},{"issue":"3","key":"e_1_2_13_35_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0749-8063(92)90067-L","article-title":"Serial magnetic resonance study assessing the effects of impingement on the MR image of the patellar tendon graft","volume":"8","author":"Howell SM","year":"1992","journal-title":"Arthroscopy"},{"issue":"1","key":"e_1_2_13_36_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/036354659502300107","article-title":"Revascularization of a human anterior cruciate ligament graft during the first two years of implantation","volume":"23","author":"Howell SM","year":"1995","journal-title":"Am J Sports Med"},{"issue":"11","key":"e_1_2_13_37_1","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1002\/ksa.12300","article-title":"Nonanatomic femoral tunnel placement increases the risk of subsequent meniscal surgery after ACLR: part II\u2014patients without recurrent ACL injury","volume":"32","author":"Inoue J","year":"2024","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"5","key":"e_1_2_13_38_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/03635465010290051301","article-title":"Development and validation of the International Knee Documentation Committee Subjective Knee Form","volume":"29","author":"Irrgang JJ","year":"2001","journal-title":"Am J Sports Med"},{"issue":"3","key":"e_1_2_13_39_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/ksa.12710","article-title":"The addition of lateral extra\u2010articular augmentation procedures to bone\u2010tendon\u2010bone or quadriceps autograft anterior cruciate ligament reconstruction does not negatively affect physical or psychological readiness for return to sport at 6 and 9 months","volume":"34","author":"LaPrade CM","year":"2026","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"3","key":"e_1_2_13_40_1","first-page":"116","article-title":"Anterior cruciate ligament reconstruction with use of autologous quadriceps tendon graft","volume":"89","author":"Lee S","year":"2007","journal-title":"J Bone Jt Surg"},{"issue":"5","key":"e_1_2_13_41_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2106\/JBJS.16.00241","article-title":"The relationship between ACL femoral tunnel position and postoperative MRI signal intensity","volume":"99","author":"Lee SM","year":"2017","journal-title":"J Bone Jt Surg"},{"issue":"10","key":"e_1_2_13_42_1","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1007\/s00167-016-4252-5","article-title":"MRI\u2010based ACL graft maturity does not predict clinical and functional outcomes during the first year after ACL reconstruction","volume":"25","author":"Li H","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"10","key":"e_1_2_13_43_1","doi-asserted-by":"crossref","DOI":"10.1177\/2325967114553552","article-title":"Correlation analysis of potential factors influencing graft maturity after anterior cruciate ligament reconstruction","volume":"2","author":"Li H","year":"2014","journal-title":"Orthop J Sports Med"},{"issue":"1","key":"e_1_2_13_44_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13018-023-04512-y","article-title":"Effect of bone marrow aspiration concentrate and platelet\u2010rich plasma combination in anterior cruciate ligament reconstruction: a randomized, prospective, double\u2010blinded study","volume":"19","author":"Lin YC","year":"2024","journal-title":"J Orthop Surg Res"},{"issue":"5","key":"e_1_2_13_45_1","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/ksa.12451","article-title":"No difference in clinical outcome between quadriceps tendon anterior cruciate ligament reconstruction with and without bone block: results from the Danish Knee Ligament Registry","volume":"33","author":"Lind M","year":"2025","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"10","key":"e_1_2_13_46_1","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1007\/s00167-021-06777-4","article-title":"Anterior cruciate ligament autograft maturation on sequential postoperative MRI is not correlated with clinical outcome and anterior knee stability","volume":"30","author":"Lutz PM","year":"2022","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"3","key":"e_1_2_13_47_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00167-014-3302-0","article-title":"Graft maturity of the reconstructed anterior cruciate ligament 6 months postoperatively: a magnetic resonance imaging evaluation of quadriceps tendon with bone block and hamstring tendon autografts","volume":"23","author":"Ma Y","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"2","key":"e_1_2_13_48_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/03635465010290021601","article-title":"Development and evaluation of an activity rating scale for disorders of the knee","volume":"29","author":"Marx RG","year":"2001","journal-title":"Am J Sports Med"},{"issue":"2","key":"e_1_2_13_49_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00590-021-03198-4","article-title":"Influence of platelet\u2010rich plasma (PRP) analogues on healing and clinical outcomes following anterior cruciate ligament (ACL) reconstructive surgery: a systematic review","volume":"33","author":"McRobb J","year":"2022","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"2","key":"e_1_2_13_50_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00004728-199803000-00021","article-title":"MR evaluation of human anterior cruciate ligament autograft on oblique axial imaging","volume":"22","author":"Murakami Y","year":"1998","journal-title":"J Comput Assist Tomogr"},{"issue":"12","key":"e_1_2_13_51_1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.arthro.2008.07.016","article-title":"Effects of platelet concentrate and a bone plug on the healing of hamstring tendons in a bone tunnel","volume":"24","author":"Orrego M","year":"2008","journal-title":"Arthroscopy"},{"issue":"9","key":"e_1_2_13_52_1","doi-asserted-by":"crossref","DOI":"10.1177\/23259671211023512","article-title":"Effect of time on MRI appearance of graft after ACL reconstruction: a comparison of autologous hamstring and quadriceps tendon grafts","volume":"9","author":"Panos JA","year":"2021","journal-title":"Orthop J Sports Med"},{"issue":"1","key":"e_1_2_13_53_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00264-024-06380-5","article-title":"Biological augmentation of anterior cruciate ligament reconstruction with bone marrow aspirate concentrate: a systematic review and meta\u2010analysis of randomised controlled trials","volume":"49","author":"Park JY","year":"2025","journal-title":"Int Orthop"},{"issue":"7","key":"e_1_2_13_54_1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1177\/0363546514530088","article-title":"Incidence of second ACL injuries 2 years after primary ACL reconstruction and return to sport","volume":"42","author":"Paterno MV","year":"2014","journal-title":"Am J Sports Med"},{"issue":"4","key":"e_1_2_13_55_1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/s00167-019-05665-2","article-title":"Anatomic ACL reconstruction reduces risk of post\u2010traumatic osteoarthritis: a systematic review with minimum 10\u2010year follow\u2010up","volume":"28","author":"Rothrauff BB","year":"2020","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"2","key":"e_1_2_13_56_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1148\/radiol.2492071651","article-title":"Anterior cruciate ligament reconstruction grafts: MR imaging features at long\u2010term follow\u2010up\u2014correlation with functional and clinical evaluation","volume":"249","author":"Saupe N","year":"2008","journal-title":"Radiology"},{"issue":"11","key":"e_1_2_13_57_1","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1002\/ksa.12304","article-title":"No difference was found between double\u2010bundle and single\u2010bundle anterior cruciate ligament reconstructions in terms of osteoarthritis at 15\u2010year follow\u2010up","volume":"32","author":"Sepp\u00e4nen A","year":"2024","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"9","key":"e_1_2_13_58_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00167-010-1046-z","article-title":"Femoral tunnel enlargement after anatomic ACL reconstruction: a biological problem?","volume":"18","author":"Silva A","year":"2010","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"8","key":"e_1_2_13_59_1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1177\/0363546517698676","article-title":"The graft bending angle can affect early graft healing after anterior cruciate ligament reconstruction: in vivo analysis with 2 years' follow\u2010up","volume":"45","author":"Tashiro Y","year":"2017","journal-title":"Am J Sports Med"},{"key":"e_1_2_13_60_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00003086-198509000-00007","article-title":"Rating systems in the evaluation of knee ligament injuries","volume":"198","author":"Tegner Y","year":"1985","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"e_1_2_13_61_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1177\/03635465030310030401","article-title":"Determination of time of biologic fixation after anterior cruciate ligament reconstruction with hamstring tendons","volume":"31","author":"Uchio Y","year":"2003","journal-title":"Am J Sports Med"},{"issue":"6","key":"e_1_2_13_62_1","doi-asserted-by":"crossref","DOI":"10.1177\/2325967119849012","article-title":"Assessment of anterior cruciate ligament graft maturity with conventional magnetic resonance imaging: a systematic literature review","volume":"7","author":"Van Dyck P","year":"2019","journal-title":"Orthop J Sports Med"},{"issue":"11","key":"e_1_2_13_63_1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.arthro.2011.06.003","article-title":"The effect of platelet concentrates on graft maturation and graft\u2013bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials","volume":"27","author":"Vavken P","year":"2011","journal-title":"Arthroscopy"},{"issue":"12","key":"e_1_2_13_64_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/bjsports-2015-095952","article-title":"ACL injuries in men's professional football: a 15\u2010year prospective study on time trends and return\u2010to\u2010play rates reveals only 65% of players still play at the top level 3 years after ACL rupture","volume":"50","author":"Wald\u00e9n M","year":"2016","journal-title":"Br J Sports Med"},{"issue":"1","key":"e_1_2_13_65_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1186\/s12891-022-05912-7","article-title":"Clinical application of modified Crain classification in the design of anterior cruciate ligament reconstruction with remnant preservation","volume":"23","author":"Wang Z","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"issue":"6","key":"e_1_2_13_66_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/03635465010290061401","article-title":"Biomechanical properties and vascularity of an anterior cruciate ligament graft can be predicted by contrast\u2010enhanced magnetic resonance imaging. A two\u2010year study in sheep","volume":"29","author":"Weiler A","year":"2001","journal-title":"Am J Sports Med"},{"issue":"7","key":"e_1_2_13_67_1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1177\/0363546515621554","article-title":"Risk of secondary injury in younger athletes after anterior cruciate ligament reconstruction: a systematic review and meta\u2010analysis","volume":"44","author":"Wiggins AJ","year":"2016","journal-title":"Am J Sports Med"},{"issue":"6","key":"e_1_2_13_68_1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3348\/kjr.2015.16.6.1313","article-title":"Bone tunnel diameter measured with CT after anterior cruciate ligament reconstruction using double\u2010bundle autohamstring tendons: clinical implications","volume":"16","author":"Yoon SJ","year":"2015","journal-title":"Korean J Radiol"},{"key":"e_1_2_13_69_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1455225","article-title":"ACL injury management: a comprehensive review of novel biotherapeutics","volume":"12","author":"Yu X","year":"2024","journal-title":"Front Bioeng Biotechnol"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.70484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ksa.70484","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.70484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:46:44Z","timestamp":1781880404000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/ksa.70484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":68,"alternative-id":["10.1002\/ksa.70484"],"URL":"https:\/\/doi.org\/10.1002\/ksa.70484","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2026-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ksa.70484"}}