{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:31:58Z","timestamp":1786365118392,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The adoption of interventions in osteoarthritis and musculoskeletal care frequently precedes the availability of robust long\u2010term evidence, creating the conditions for subsequent medical reversal. Recent findings raising concern about possible adverse neurocognitive associations with glucosamine use challenge the assumption that widely used supplements are necessarily biologically inert, although their causal significance and direct relevance to routine osteoarthritis management remain uncertain. In contrast, 10\u2010year follow\u2010up evidence after arthroscopic partial meniscectomy for degenerative meniscal tears provides a more established example of medical reversal, demonstrating no sustained clinical benefit over sham surgery and raising concern regarding structural harm. Evidence concerning repeated intra\u2010articular corticosteroid injections similarly illustrates the limitations of relying on biological plausibility or short\u2010term symptomatic outcomes. These examples, while differing in evidentiary maturity, support a common principle: orthopaedic interventions should be evaluated according to rigorous comparative evidence and durable patient\u2010centred outcomes. Clinicians should communicate uncertainty, avoid treating structural abnormalities or mechanistic rationale as sufficient indications for intervention, and remain willing to revise established practices when stronger evidence emerges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ksa.70578","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:01:16Z","timestamp":1786363276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteoarthritis management through medical reversal: Glucosamine, Alzheimer's disease risk, and long\u2010term outcomes after arthroscopic partial meniscectomy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-5770","authenticated-orcid":false,"given":"Mehmet S\u00fcleyman","family":"Abul","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology Metin Sabanci Baltalimani Bone Diseases Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Parvizi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Acibadem University, Acibadem Maslak Hospital, International Joint Center Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Skowronek","sequence":"additional","affiliation":[{"name":"Orthopaedic and Trauma Department \u017beromski Specialist Hospital Krak\u00f3w Poland"},{"name":"SPORTOKLINIK Orthopaedics and Sports Medicine Center Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahri","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Nisantasi Orthopedics Center \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Tuncay","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Acibadem University, Acibadem Maslak Hospital, International Joint Center Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Hirschmann","sequence":"additional","affiliation":[{"name":"University Department of Orthopedic Surgery and Traumatology, Kantonsspital Baselland Bruderholz Switzerland"},{"name":"Department of Clinical Research, Research Group Michael T. Hirschmann, Regenerative Medicine &amp; Biomechanics University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-7454","authenticated-orcid":false,"given":"Mahmut Enes","family":"Kayaalp","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital Istanbul Turkey"},{"name":"Department of Orthopaedics and Traumatology University Hospital Brandenburg\/Havel, Brandenburg Medical School Theodor Fontane Brandenburg Germany"},{"name":"Faculty of Health Sciences Brandenburg Brandenburg Medical School Theodor Fontane Brandenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(91)90064-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(92)90023-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-21-01233"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-026-01538-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2516079"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.5283"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-022-07040-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70290"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1353\/book.49286"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12674"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-017-4473-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.70314"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-017-4458-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305189"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02816-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01295-6"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.70578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ksa.70578","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.70578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:01:17Z","timestamp":1786363277000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/ksa.70578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":16,"alternative-id":["10.1002\/ksa.70578"],"URL":"https:\/\/doi.org\/10.1002\/ksa.70578","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"2026-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ksa.70578"}}