{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:22:38Z","timestamp":1790036558762,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,6]],"date-time":"2009-01-06T00:00:00Z","timestamp":1231200000000},"content-version":"vor","delay-in-days":11328,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:p>Metabolic dysfunction is one of many factors mentioned as a primary or contributing cause of M\u00e9ni\u00e8re's disease. This evaluation consists of three parts: (1) thyroid studies, (2) five\u2010hour glucose tolerance test, and (3) adrenal and pituitary tests.<\/jats:p><jats:p>Ninety\u2010eight patients with M\u00e9ni\u00e8re's disease are evaluated with an FTA absorption test. neuro\u2010otologic, allergic, and metabolic studies. The results of the metabolic evaluation are reviewed.<\/jats:p><jats:p>Thyroid function is evaluated with the thyroxine (T<jats:sub>4<\/jats:sub>) free index test and the serum\u2010bound thyroxine (T<jats:sub>4<\/jats:sub>) test of Murphy\u2010Pattee. Although 27% had low normal or hypothyroid findings, it was of clinical significance in only 17% of the patients.<\/jats:p><jats:p>The five\u2010hour glucose tolerance test was used to diagnose hyperglycemia and hypoglycemia.<\/jats:p><jats:p>Thirty percent of the 70 patients evaluated had an abnormal five\u2010hour glucose tolerance test. The 19 patients (28%) with a hypoglycemic curve are almost equally divided between a flat glucose tolerance curve, a reactive hypoglycemic curve, and chemical or latent diabetic curve. A manifest diabetic curve was present in two patients. Hypoglycemia was not a primary factor in M\u00e9ni\u00e8re's disease but was an important contributing cause in 12 patients that responded to a combination of dietary, allergic or endocrine therapy.<\/jats:p><jats:p>The symptoms of M\u00e9ni\u00e8re's disease often become manifest during periods of stress. The adrenal pituitary axis plays a vital role in man's reaction to stress. For this reason, hypoadrenal function was suggested as an etiology in some patients with M\u00e9ni\u00e8re's disease.<\/jats:p><jats:p>In this study two recently devised tests were used to measure adrenocortical reserve: (1) ACTH plasma cortisol stimulation test, and (2) insulin stimulation test.<\/jats:p><jats:p>Sixty of the 98 patients were evaluated with the ACTH plasma cortisol stimulation test, and one\u2010third had a lowered adrenocortical reserve. Further endocrine studies are being performed to determine the presence of a specific endocrine problem.<\/jats:p><jats:p>After evaluation of 98 patients with M\u00e9ni\u00e8re's disease, we concluded the following:<jats:list><jats:list-item><jats:p>The five\u2010hour glucose tolerance test is helpful in identifying hypoglycemia, which may be a contributing factor in M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Non\u2010myxedematous hypothyroidism may play an important role in some patients with M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p>Further endocrine studies will be necessary to determine the significance of the lowered adrenocortical reserve as shown by the ACTH plasma cortisol stimulation test.<\/jats:p>","DOI":"10.1002\/lary.1978.88.1.122","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T11:41:26Z","timestamp":1488195686000},"page":"122-129","source":"Crossref","is-referenced-by-count":20,"title":["Metabolic Aspects Of M\u00e9Ni\u00e8Re's Disease"],"prefix":"10.1002","volume":"88","author":[{"given":"W. Hugh","family":"Powers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1968.00760060557024"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196707000-00001"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196907000-00010"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947007900519"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196708000-00016"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540740205"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195908000-00004"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1960.03770030155029"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1288\/00005537-195108000-00001","article-title":"Some Aspects of Inner Ear Therapy","volume":"61","author":"Hilcer J. A.","year":"1951","journal-title":"The Laryngoscope"},{"key":"e_1_2_1_11_1","first-page":"1869","article-title":"The Hypoadrenocortical State and Its Management","volume":"58","author":"Tintera J. W.","year":"1955","journal-title":"N. York J. Med."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1969.11697307"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-32-2-188"},{"key":"e_1_2_1_14_1","first-page":"377","article-title":"Hypoadrenocorticism and Endocrinologic Treatment of M\u00e9ni\u00e8re's Disease","volume":"62","author":"Goldman H. B.","year":"1962","journal-title":"N. Y. State J. 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