{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:21Z","timestamp":1786978101978,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T00:00:00Z","timestamp":1232928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Evaluate the impact of primary site stage and cervical metastasis on the survival of patients with squamous cell carcinoma (SCC) of the hard palate or maxillary alveolus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Cross\u2010sectional population analysis of prospectively maintained database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cases of hard palate and maxillary alveolus SCC from 1988\u20132004 were extracted from the Surveillance, Epidemiology, and End Results database. Demographic data and extent of disease were extracted for each case, and T\u2010stage, and N\u2010stage were computed. Survival differences according to T\u2010stage and N\u2010stage were determined with the Kaplan\u2010Meier method and the log\u2010rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Four hundred eleven cases of maxillary alveolus and 314 cases of hard palate SCC were identified, for a total of 725 cases (53.9% female, mean age: 70.9 years). The prevalence of cervical metastasis was not significantly different according to primary site (\n                      <jats:italic>P<\/jats:italic>\n                      = .181); advanced N\u2010stage significantly correlated with more advanced T\u2010stage (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Of the 725 cases, 4.1% of T1 tumors, 14.9% of T2 tumors, 10.3% of T3 tumors, and 24.7% of T4 tumors had cervical nodal metastases. The mean overall survivals were 96.5, 69.1, 67.8, and 49.3 months for T1\u2013T4 tumors, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). With regard to N\u2010stage, the mean survivals were 73.7, 69.7, 29.8, and 5.5 months for N0\u2013N3 lesions, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Nodal metastasis effect on survival remained significant (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .039) in stratified survival analysis except for T3 lesions (\n                      <jats:italic>P<\/jats:italic>\n                      = .205).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Survival in patients with SCC of either the hard palate or maxillary alveolus is significantly influenced by T\u2010stage and a nonnegligible rate of cervical nodal metastases. Laryngoscope, 119:312\u2013315, 2009<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.20054","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T03:09:53Z","timestamp":1237259393000},"page":"312-315","source":"Crossref","is-referenced-by-count":52,"title":["Survival impact of nodal disease in hard palate and maxillary alveolus cancer"],"prefix":"10.1002","volume":"119","author":[{"given":"Harrison W.","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00136-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00077-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2003.09.004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000233607.41540.28"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.017"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.09.001"},{"key":"e_1_2_6_8_2","unstructured":"Surveillance Epidemiology and End Results (SEER) Program(www.seer.cancer.gov) SEER*Stat Database: Incidence\u2014SEER 9 Regs Limited\u2010Use Nov 2007 Sub (1973\u20132005) <Katrina\/Rita Population Adjustment>\u2014Linked To County Attributes\u2014Total U.S. 1969\u20132005 Counties National Cancer Institute DCCPS Surveillance Research Program Cancer Statistics Branch released April 2008 based on the November 2007 submission."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00101-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00149-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(70)90054-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(81)90373-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318033c800"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181671b3d"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00049-0"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20054","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.20054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T08:49:53Z","timestamp":1697100593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.20054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,26]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/lary.20054"],"URL":"https:\/\/doi.org\/10.1002\/lary.20054","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,26]]}}}