{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:36Z","timestamp":1772118816918,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives\/Hypothesis:<\/jats:title>\n                    <jats:p>With low\u2010dose and titration protocols, subsequent intratympanic (IT) gentamicin injections are frequently necessary for vertigo control in M\u00e9ni\u00e8re's disease. To date, studies have not provided detailed descriptions of the time course of recurrent vertigo and repeated injections. Our objective is to provide such a description with a Kaplan\u2010Meier survival analysis, which may enable accurate predictions of the probability of recurrent vertigo after a given time or number of injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Injections of IT gentamicin were administered for unilateral definite M\u00e9ni\u00e8re's disease. One injection (or rarely more) in a 6\u2010week period constituted a \u201cround.\u201d Repeat rounds were given when needed for control of recurrent vertigo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used a Kaplan\u2010Meier method to quantify percentages of patients with control of vertigo over an 8\u2010year period. A separate curve was created for each number of rounds, and failure for each was defined as the need for an additional round.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 78 patients, 75 (96%) achieved sufficient vertigo control to avoid ablative surgery, and 42 (54%) required only one round. Thirty\u2010six (46%) required multiple rounds. The probability of needing another round increased with each subsequent one, through four rounds. The median times to the next round after one, two, or three rounds were 148, 118, and 124 days, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>More than half of patients need only one round of IT gentamicin injections. With each additional round through the fourth one, the probability of additional rounds increases. Nevertheless, the majority (96%) of patients do not need ablative surgery after IT gentamicin. Laryngoscope, 2009<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.20055","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T14:07:20Z","timestamp":1234361240000},"page":"792-798","source":"Crossref","is-referenced-by-count":25,"title":["Time course of repeated intratympanic gentamicin for m\u00e9ni\u00e8re's disease"],"prefix":"10.1002","volume":"119","author":[{"given":"Kimanh D.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd B.","family":"Minor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Della Santina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"3209","volume-title":"Otolaryngology\u2014Head and Neck Surgery","author":"Schessel D","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e31815dbafc"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00463571"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00023"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300102879"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08658.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200103000-00016"},{"key":"e_1_2_6_10_2","first-page":"435","article-title":"Intratympanic gentamicin injection for the treatment of M\u00e9ni\u00e8re's disease","volume":"19","author":"Youssef TF","year":"1998","journal-title":"Am J Otol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200207000-00018"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on hearing and equilibrium guidelines for the diagnosis and evaluation of therapy in M\u00e9ni\u00e8re's disease","volume":"113","author":"Monsell EM","year":"1995","journal-title":"Otalaryngol Head Neck Surg"},{"key":"e_1_2_6_13_2","first-page":"209","article-title":"Intratympanic gentamicin for control of vertigo in M\u00e9ni\u00e8re's disease: vestibular signs that specify completion of therapy","volume":"20","author":"Minor LB","year":"1999","journal-title":"Am J Otol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511401007"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600951475"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31815aea05"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411000204"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00160.2004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-007-0093-8"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109138398"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.112310"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1990.tb00796.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00013"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20055","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.20055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T16:47:01Z","timestamp":1696783621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.20055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,11]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1002\/lary.20055"],"URL":"https:\/\/doi.org\/10.1002\/lary.20055","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1160233.620531","asserted-by":"object"}]},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,11]]}}}