{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:24:22Z","timestamp":1790616262758,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T00:00:00Z","timestamp":1232496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>To determine the roles of vascular endothelial growth factor (VEGF), Angiopoietin (Ang)\u20101, and Ang\u20102 in nasal polyps (NPs) by assaying expression patterns and evaluating the effects of dexamethasone (DEX) on these factors in organ cultured NPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Expression patterns of VEGF, Ang\u20101, and Ang\u20102 in NPs were compared with those in inferior turbinate mucosa samples. Tissue samples were analyzed using the enzyme\u2010linked immunosorbent assay (ELISA) and immunofluorescent staining methods. To determine the effects of DEX, NP tissues were cultured using an air\u2010liquid interface method. Cultures were maintained in the absence or presence of DEX (10 \u03bcM or 100 \u03bcM) for 24 hours, and tissue samples analyzed with ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>VEGF and Ang\u20101 levels were significantly higher, whereas the Ang\u20102 level was significantly lower in NPs, compared to inferior turbinate mucosa (<jats:italic>P<\/jats:italic> &lt; .05). In NPs, VEGF and Ang\u20101 were detected in glandular epithelial, vascular endothelial, as well as stromal inflammatory cells, whereas Ang\u20102 was detected only in stromal inflammatory cells. VEGF and Ang\u20101 levels were significantly lower, while Ang\u20102 levels were significantly higher in 100 \u03bcM DEX\u2010treated group than nontreated group (<jats:italic>P<\/jats:italic> &lt; .01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Imbalance among VEGF, Ang 1, and Ang 2 may be important in the angiogenesis of NPs. Moreover, DEX can control the expression of these factors in NPs. We suggest that VEGF and Ang\u20101 act as positive regulatory factors, and Ang\u20102 functions as a negative regulatory factor of angiogenesis in NPs. Laryngoscope, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20085","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T18:13:53Z","timestamp":1232561633000},"page":"409-413","source":"Crossref","is-referenced-by-count":16,"title":["Roles of vascular endothelial growth factor, Angiopoietin 1, and Angiopoietin 2 in nasal polyp"],"prefix":"10.1002","volume":"119","author":[{"given":"Seong Kook","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong In","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Il","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2003.01297.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114322"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5322.55"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2045"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00231-5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-9725.2003.00061.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70529-4"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b24.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.supplement_2.2106065"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210731"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.468"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/35025215"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/380439a0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607538103"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172161899"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2004.06.010"},{"key":"e_1_2_7_18_2","first-page":"767","article-title":"Influence of fluticasone propionate on the production of vascular endothelial growth factor and basic fibroblast growth factor from nasal fibroblasts in vitro","volume":"18","author":"Uchida J","year":"2004","journal-title":"In Vivo"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000177031.06112.50"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20085","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.20085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:51:11Z","timestamp":1697115071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.20085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,21]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/lary.20085"],"URL":"https:\/\/doi.org\/10.1002\/lary.20085","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,21]]}}}