{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:55:11Z","timestamp":1760982911138},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>The purpose of this study was to investigate possible preventive effects of anti\u2010intercellular adhesion molecule\u20101 antibody (anti\u2010ICAM\u20101 Ab) on noise\u2010induced cochlear damage as assessed by changes in auditory thresholds and cochlear blood flow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>A controlled animal study. Pretreated rats with anti\u2010ICAM\u20101 Ab or saline control, followed with exposure to 72 continuous hours of broad band noise (107 dB SPL), and 24 hours after noise exposure treated again with anti\u2010ICAM\u20101 Ab or saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Eighteen healthy male Fischer rats (200\u2013250 g) were used. Sixteen were randomly selected to study noise\u2010induced temporary threshold shifts. The remaining two rats were used to study cochlear blood flow (CBF), using laser Doppler flowmetry and blood pressure measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Rats treated with anti\u2010ICAM\u20101 Ab (1.875 mg\/kg, intravenously) showed attenuated temporary threshold shifts (TTS) compared to controls. Both groups showed a partial threshold recovery 72 hours following noise exposure, normal for this noise exposure paradigm. Comparisons of baseline and post\u2010treatment measurements of CBF and mean arterial blood pressure revealed no significant changes. Anti\u2010ICAM\u20101 Ab animals displayed significantly lower mean auditory threshold shifts at all five test frequencies (<jats:italic>P<\/jats:italic> &lt; .05) when compared to control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Blocking the cascade of reactive oxygen species (ROS) generation by using anti\u2010ICAM\u2010Ab protects against noise\u2010induced hearing loss. 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