{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:45:23Z","timestamp":1791906323840,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T00:00:00Z","timestamp":1236556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>To evaluate the long\u2010term effectiveness of calcium hydroxylapatite (CaHA) vocal fold injection for patients with glottal insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Multicenter, open\u2010label, prospective clinical study of CaHA vocal fold injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Each patient served as his\/her own control. Voice\u2010related outcome measures were collected for pre\u2010injection, 1, 3, 6, and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Sixty\u2010three patients were available for evaluation. Fifty\u2010three percent of the injection procedures were done in the office. Fifty\u2010seven percent of patients were diagnosed with unilateral paralysis and 43% with glottal incompetence with mobile vocal folds. Patient satisfaction 12 months after injection showed 67% reporting a significant improvement in voice and 81% reporting at least a moderate improvement in voice. Utilizing the Voice Handicap Index\u201310, visual analog scale (vocal effort), Consensus Assessment Perceptual Evaluation V (judgments of voice severity), and objective voice measures of glottal closure (maximum phonation time and S:Z ratio), paired <jats:italic>t<\/jats:italic> tests showed significant improvements after treatment. A 22% further treatment rate was found at the 12\u2010month time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>One\u2010year results in this large cohort of patients with glottal incompetence treated with CaHA vocal fold injection demonstrate that excellent clinical results were achieved. Laryngoscope, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20126","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T17:37:40Z","timestamp":1236620260000},"page":"1033-1041","source":"Crossref","is-referenced-by-count":127,"title":["Vocal fold augmentation with calcium hydroxylapatite: Twelve\u2010month report"],"prefix":"10.1002","volume":"119","author":[{"given":"Clark A.","family":"Rosen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Gartner\u2010Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Casiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy 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