{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:50Z","timestamp":1790281790988,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T00:00:00Z","timestamp":1248998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Pritzker School of Medicine, Section of Otolaryngology, University of Chicago"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>In suspected cases of Sjogren syndome (SS), patients are often referred for a labial minor salivary gland biopsy. However, studies have shown this test to be unreliable. Pathologic misinterpretation and immunosuppressive medications may affect the results of the biopsy. As a result, it is best to perform this procedure only when necessary. The purpose of the current study was to review clinical signs and symptoms of patients who underwent a lip biopsy to determine which patients benefited most from this procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A retrospective chart review of patients referred to otolaryngology for a lip biopsy for the diagnosis of SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Joint pain, salivary gland swelling, and abnormal serology (anti\u2010Sjogren syndrome A\/anti\u2010Sjogren syndrome B) were more prevalent in the positive lip biopsy group (grade = 3 or 4). Out of the 12 patients who had both sicca symptoms and positive serology, nine (75%) had a grade = 4. Presence of sicca symptoms and positive serology were predictive of a positive biopsy (<jats:italic>P<\/jats:italic> = .017). Excluding those patients who were on immunosuppression for more than 6 weeks prior to the biopsy, the correlation became stronger (<jats:italic>P<\/jats:italic> = .011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In this study, clinical presentation of sicca symptoms and positive serology reliably predicted the results of a lip biopsy. The results of this study suggest that patients with clear criterion for SS may not require a lip biopsy, especially those patients on immunosuppression. When physicians suspect SS, a thorough clinical and laboratory examination is necessary to determine if a patient will benefit from a minor salivary gland biopsy. Laryngoscope, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20292","type":"journal-article","created":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T18:27:35Z","timestamp":1249064855000},"page":"1922-1926","source":"Crossref","is-referenced-by-count":26,"title":["The minor salivary gland biopsy as a diagnostic tool for Sjogren syndrome"],"prefix":"10.1002","volume":"119","author":[{"given":"Ravinder","family":"Bamba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadera J.","family":"Sweiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Langerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome B.","family":"Taxy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.21.5.656"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90417-4"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270205"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300705.x"},{"key":"e_1_2_7_7_2","first-page":"938","article-title":"Change in final diagnosis on second evaluation of labial minor salivary gland biopsies","volume":"29","author":"Vivino FB","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23579"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31804654f7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508088941"},{"key":"e_1_2_7_11_2","first-page":"1515","article-title":"Minor salivary gland biopsies in patients investigated for primary Sjogren's syndrome: a review of 187 patients","volume":"20","author":"Wise CM","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331111"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.5.511"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307085115"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310412"},{"key":"e_1_2_7_16_2","first-page":"479","article-title":"Lupus pneumonitis and anti\u2010SSA (Ro) antibodies","volume":"16","author":"Boulware DW","year":"1989","journal-title":"J Rheumatol"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.20292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:11:58Z","timestamp":1696871518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.20292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,31]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1002\/lary.20292"],"URL":"https:\/\/doi.org\/10.1002\/lary.20292","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,31]]}}}