{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:36:49Z","timestamp":1783093009221,"version":"3.54.6"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Radiofrequency (RF) surgery of the soft palate (SP) is an established treatment option for the treatment of snoring. Due to its minimally invasive character, it has received attention in the management of mild obstructive sleep apnea syndrome (OSAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>The aim of this study was to assess the efficacy and the occurrence of adverse events after single\u2010stage SP RF surgery in patients with mild OSAS in a randomized single\u2010blinded placebo\u2010controlled trial in an outpatient department at a tertiary care center, academic teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Thirty\u2010two patients with mild OSAS (apnea\u2010hypopnea index [AHI] 5\u201315, body mass index &lt;35) were randomized to receive a single session of RF surgery or placebo (insertion of applicator without energy delivery) with local anesthesia. The primary outcome measures were (AHI), Epworth Sleepiness Scale, and a 36\u2010item short\u2010form health survey quality\u2010of\u2010life questionnaire. The secondary measures were the soft tissue airway parameters in cephalometric radiographs, snoring scores, and rates of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Neither objectively measured significances (active AHI 11.0 [5.0\u20139.0] to 13.0 [2.0\u201326.0] and placebo AHI 12.0 [5.0\u20138.0] to 11.0 [1.0\u201329.0], <jats:italic>P<\/jats:italic> = .628), nor were trends of a diminishing effect on symptoms of mild OSAS found in the treatment arms. No significant changes in the soft tissue airway parameters occurred. One patient (5.9%) in the active treatment group was cured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>RF surgery of SP is not recommended as a single\u2010stage approach in mild OSAS. Laryngoscope, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20562","type":"journal-article","created":{"date-parts":[[2009,6,6]],"date-time":"2009-06-06T10:57:27Z","timestamp":1244285847000},"page":"1621-1627","source":"Crossref","is-referenced-by-count":37,"title":["Radiofrequency surgery of the soft palate in the treatment of mild obstructive sleep apnea is not effective as a single\u2010stage procedure: A randomized single\u2010blinded placebo\u2010controlled trial"],"prefix":"10.1002","volume":"119","author":[{"given":"Leif J. J.","family":"B\u00e4ck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Liukko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Rantanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko S.","family":"Peltola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Partinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Ylikoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-008-0188-4"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180514d08"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1588OC"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500303"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.2.244"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/sleep\/27.3.551","article-title":"Radiofrequency surgery of the soft palate in the treatment of snoring: a review of the literature","volume":"2007","author":"Stuck B","year":"2004","journal-title":"Sleep"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.7.847"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2104110"},{"key":"e_1_2_7_10_2","first-page":"1","article-title":"Hypertonic saline injections to enhance the radiofrequency thermal ablation effect in the treatment of base of tongue in obstructive sleep apnea patients: a pilot study","volume":"10","author":"Back L","year":"2008","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_7_11_2","first-page":"193","article-title":"Radiofrequency tissue reduction of the palate in patients with moderate sleep\u2010disordered breathing","volume":"30","author":"Brown FJ","year":"2001","journal-title":"J Laryngol Otol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00033"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0959-5"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.06.012"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20562","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.20562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T13:43:49Z","timestamp":1696859029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.20562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,21]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1002\/lary.20562"],"URL":"https:\/\/doi.org\/10.1002\/lary.20562","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,21]]}}}