{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:12:06Z","timestamp":1782753126221,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T00:00:00Z","timestamp":1249257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]},{"name":"GlaxoSmithKline, Sweden"},{"name":"Pfizer AB, Sweden"},{"name":"Acta Otolaryngologica Foundation"},{"name":"Rosa and Emanuel Nachmansson's Foundation"},{"name":"Stig and Ragna Gorthon Foundation"},{"name":"Torsten Birger Segerfalk Foundation"},{"name":"Margit Arstrup's Foundation"},{"name":"County Council of Sk\u00e5ne"},{"name":"Helsinki University Central Hospital Research Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>We investigated how study design affects the rate of recovery in Bell's palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective, randomized, double\u2010blind, placebo\u2010controlled, multicenter trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Data were extracted from the Scandinavian Bell's palsy study, which included 829 patients. The study design was factorial; 416 patients given prednisolone, 413 not given prednisolone, 413 patients given valacyclovir, 416 not given valacyclovir. Data were analyzed with intention\u2010to\u2010treat principle and complete\u2010case analysis methods and recovery was defined as Sunnybrook score 100, House\u2010Brackmann grade I or \u2264grade II at 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>With the intention\u2010to\u2010treat principle and last\u2010observation\u2010carried\u2010forward method (n = 829) and recovery defined as Sunnybrook 100, 300 of the 416 patients (72%) receiving prednisolone had recovered compared with 237 of the 413 (57%) who did not receive prednisolone (<jats:italic>P<\/jats:italic> &lt; .0001). With recovery defined as House\u2010Brackmann grade I, the corresponding recovery rates were 324 of 416 (78%) and 266 of 413 (64%) (<jats:italic>P<\/jats:italic> &lt; .0001). With complete\u2010case analysis and recovery defined House\u2010Brackmann grade I (n = 782), 335 of 389 patients (86%) given prednisolone recovered compared with 277 of 393 (70%) in the group not given prednisolone (<jats:italic>P<\/jats:italic> &lt; .0001). With recovery defined as House\u2010Brackmann \u2264grade II (n = 797), the corresponding recovery rates were 380 of 396 (96%) and 353 of 401 (88%) (<jats:italic>P<\/jats:italic> &lt; .0001). The analysis method affected the recovery rates in the valacyclovir and no\u2010valacyclovir groups in a similar way as in the prednisolone and no\u2010prednisolone groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Recovery rates in a Bell's palsy study are substantially affected by the choice of analysis method and definition of recovery. Laryngoscope, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20626","type":"journal-article","created":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T20:40:38Z","timestamp":1249332038000},"page":"2046-2050","source":"Crossref","is-referenced-by-count":30,"title":["The effect of study design and analysis methods on recovery rates in Bell's 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