{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:45:39Z","timestamp":1779140739659,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI 07\/0035"],"award-info":[{"award-number":["PI 07\/0035"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Bilateral Meniere's disease (BMD) is a severe disease that usually results in bilateral severe or profound sensorineural hearing loss and chronic disequilibrium with loss of vestibular function. We examined single nucleotide polymorphisms (SNPs) in the <jats:italic>PTPN22<\/jats:italic> and <jats:italic>CTLA4<\/jats:italic> genes in Caucasian patients with BMD to assess the possible association between these polymorphism and the predisposition and clinical expression of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>A case control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The functional protein tyrosine phosphatase type 22 (<jats:italic>PTPN22<\/jats:italic>) SNP (rs2476601, 1858C\/T) and <jats:italic>CTLA4<\/jats:italic> SNP (rs231775, 49A\/G) were analyzed in 52 patients with BMD and 348 healthy controls by a TaqMan 5\u2032 allelic discrimination assay. Data were analyzed by a \u03c7<jats:sup>2<\/jats:sup> test with Fisher exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>No association was found between the +49A\/G <jats:italic>CTLA4<\/jats:italic> genotype and BMD patients. However, the heterozygote <jats:italic>PTPN22<\/jats:italic> 1858C\/T genotype was present at a significantly higher frequency in BMD patients than in controls (odds ratio = 2.25, 95% confidence interval: 1.09\u20134.62; <jats:italic>P<\/jats:italic> = .04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>These results suggest that the <jats:italic>PTPN22<\/jats:italic> 1858C\/T genotype may confer differential susceptibility to BMD in the Spanish population and support an autoimmune etiology for BMD. Laryngoscope, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20650","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T14:42:04Z","timestamp":1253803324000},"page":"103-107","source":"Crossref","is-referenced-by-count":30,"title":["Association of a functional polymorphism of <i>PTPN22<\/i> encoding a lymphoid protein phosphatase in bilateral Meniere's disease"],"prefix":"10.1002","volume":"120","author":[{"given":"Jose A.","family":"Lopez\u2010Escamez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Saenz\u2010Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Gazquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herminio","family":"Perez\u2010Garrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Lopez\u2010Nevot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Lopez\u2010Nevot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199103000-00001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199512000-00016"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780050060010"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200207000-00021"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01621"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072502753451896"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20347"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031854"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.1.143"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.04.015"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/422827"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1204-1248"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1323"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399405009981"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease. 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