{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:11:40Z","timestamp":1763057500612,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T00:00:00Z","timestamp":1260230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health intramural research funds","award":["Z01-DC000039","Z01-DC000060","Z01-DC000064"],"award-info":[{"award-number":["Z01-DC000039","Z01-DC000060","Z01-DC000064"]}]},{"name":"Intramural Research Program of the National Human Genome Research Institute"},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Identify correlations among <jats:italic>SLC26A4<\/jats:italic> genotype, cochlear structural anomalies, and hearing loss associated with enlargement of the vestibular aqueduct (EVA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective cohort survey, National Institutes of Health, Clinical Center, a federal biomedical research facility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Eighty\u2010three individuals, 11 months to 59 years of age, with EVA in at least one ear were studied. Correlations among pure\u2010tone hearing thresholds, number of mutant <jats:italic>SLC26A4<\/jats:italic> alleles, and the presence of cochlear anomalies detected by computed tomography or magnetic resonance imaging were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Linear mixed\u2010effects model indicated significantly poorer hearing in ears with EVA in individuals with two mutant alleles of <jats:italic>SLC26A4<\/jats:italic> than in those with EVA and a single mutant allele (<jats:italic>P<\/jats:italic> = .012) or no mutant alleles (<jats:italic>P<\/jats:italic> = .007) in this gene. There was no detectable relationship between degree of hearing loss and the presence of structural cochlear anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The number of mutant alleles of <jats:italic>SLC26A4<\/jats:italic>, but not the presence of cochlear anomalies, has a significant association with severity of hearing loss in ears with EVA. This information will be useful for prognostic counseling of patients and families with EVA. Laryngoscope, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20722","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T19:30:26Z","timestamp":1260300626000},"page":"384-389","source":"Crossref","is-referenced-by-count":71,"title":["<i>SLC26A4<\/i> genotype, but not cochlear radiologic structure, is correlated with hearing loss in ears with an enlarged vestibular aqueduct"],"prefix":"10.1002","volume":"120","author":[{"given":"Kelly A.","family":"King","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Yoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Zalewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C.","family":"Madeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ani","family":"Manichaikul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon P.","family":"Pryor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Ferruggiaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Eisenman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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