{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:58:47Z","timestamp":1790715527329,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T00:00:00Z","timestamp":1254700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International Hearing Foundation","award":["NIDCD\/3U24DC008559-03S109"],"award-info":[{"award-number":["NIDCD\/3U24DC008559-03S109"]}]},{"name":"Starkey Foundation, and the Ministry of Education, Culture, Sports, Science and Technology, Japan","award":["19591970"],"award-info":[{"award-number":["19591970"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The purpose of this study was to determine the normal volume ranges of cochlear duct, saccule, and utricle, and to assess endolymphatic hydrops in M\u00e9ni\u00e8re disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Retrospective temporal bone study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Three\u2010dimensional (3\u2010D) images of membranous labyrinth were reconstructed from 31 normal temporal bones, six temporal bones from three patients with bilateral M\u00e9ni\u00e8re disease, and 16 temporal bones from eight patients with unilateral M\u00e9ni\u00e8re disease. Volumes of each part of membranous labyrinth were measured in each temporal bone group after 3\u2010D reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The mean volumes and upper normal volume limits (over the 95% confidence interval) of the cochlear duct, saccule, and utricle were 7.67 and 9.77 mm<jats:sup>3<\/jats:sup>, 2.42 and 3.68 mm<jats:sup>3<\/jats:sup>, and 10.65 and 16.45 mm<jats:sup>3<\/jats:sup>, respectively. All three patients with bilateral M\u00e9ni\u00e8re disease showed endolymphatic hydrops (excess of volume over normal limits) in both ears. Of eight patients with unilateral M\u00e9ni\u00e8re disease, five had no symptom in the contralateral ear, whereas three patients had histories of progression from unilateral to bilateral M\u00e9ni\u00e8re disease 13\u201321 years after the initial onset. All of the diseased and three of eight contralateral ears showed endolymphatic hydrops. In contrast, no hydrops was observed in any part of the membranous labyrinth in asymptomatic ears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Our findings suggest that cochleosaccular hydrops is a sensitive finding in M\u00e9ni\u00e8re disease. In addition, the volume data obtained from this study could be useful as a standard value for the assessment of hydrops in diagnostic imaging of the inner ear in M\u00e9ni\u00e8re disease. Laryngoscope, 2009<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20723","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T17:26:19Z","timestamp":1254763579000},"page":"2216-2220","source":"Crossref","is-referenced-by-count":63,"title":["Membranous labyrinth volumes in normal ears and M\u00e9ni\u00e8re disease: A three\u2010dimensional reconstruction study"],"prefix":"10.1002","volume":"119","author":[{"given":"Norimasa","family":"Morita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Kariya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Farajzadeh Deroee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahattin","family":"Cureoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenobu","family":"Nomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Nomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Paparella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,5]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Pathology of the Ear","author":"Schuknecht H","year":"1993"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200501000-00013"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909801108"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.008"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000216815.75512.03"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815c1a61"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31802c300c"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in M\u00e9ni\u00e8re's disease","volume":"113","author":"American Academy of Otolaryngology\u2010 Head and Neck Foundation, Inc","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309130918"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31815a8433"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.03.001"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815a05be"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200412000-00007"},{"key":"e_1_2_7_15_2","first-page":"1819","article-title":"Inner ear volumetric measurements using high\u2010resolution 3D T2\u2010weighted fast spin\u2010echo MR imaging: initial experience in healthy subjects","volume":"19","author":"Melhem ER","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000169635.25322.9e"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20723","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.20723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:27:56Z","timestamp":1697502476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.20723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,5]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/lary.20723"],"URL":"https:\/\/doi.org\/10.1002\/lary.20723","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,5]]}}}