{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:39:24Z","timestamp":1787060364202,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T00:00:00Z","timestamp":1262822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,3]]},"abstract":"Abstract<\/jats:title>\n \n Objectives\/Hypothesis:<\/jats:title>\n Functional partial occlusion of the glottic and subglottic areas by stenosis and strictures is challenging to manage despite a variety of surgical and endoluminal approaches that are prone to complications and inconsistent outcomes. We report here the first three human cases of glottic and subglottic narrowing treated with spray cryotherapy alone or in combination with balloon dilation.<\/jats:p>\n <\/jats:sec>\n \n Study Design:<\/jats:title>\n Institutional review board\u2010approved clinical human trial.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A 42\u2010year\u2010old female with idiopathic subglottic strictures, a 74\u2010year\u2010old female with glottic strictures and vocal cord stenosis following neck radiation, and a 33\u2010year\u2010old female with strictures from a previous tracheal stent were treated by four cycles of a 5\u2010second cryotherapy spray alone or with balloon dilation. The effects of treatment were observed up to 6 months, 12 weeks, and 9 months, respectively.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n In all cases, patency of the stenosed areas was achieved with minimal bleeding and at least some degree of normalization of the glottic and subglottic mucosa. Airway patency and laryngeal functions were restored without complications.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The use of spray cryotherapy alone or in conjunction with balloon dilation is a promising and effective therapeutic approach to treating glottic and subglottic narrowing. Laryngoscope, 2010<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.20794","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T17:21:16Z","timestamp":1262884876000},"page":"473-477","source":"Crossref","is-referenced-by-count":37,"title":["Spray cryotherapy for the treatment of glottic and subglottic stenosis"],"prefix":"10.1002","volume":"120","author":[{"given":"William S.","family":"Krimsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navara","family":"Malayaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiyad","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.03.418"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"S513","DOI":"10.14309\/00000434-200809001-01312","article-title":"Cryospray ablation for the treatment of HPV\u2010induced squamous cell carcinoma of the esophagus","volume":"103","author":"Smith J","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"S362","DOI":"10.14309\/00000434-200809001-00922","article-title":"Cryospray ablation in the treatment of hemorrhagic esophageal cancer","volume":"103","author":"Schnoll\u2010Sussman F","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.11.1226"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/028418602317314091"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2005.08.012"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.2.482"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61774-6"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)61431-2"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000231738.80952.7c"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.03.051"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1103414"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20794","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.20794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.20794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:03:44Z","timestamp":1700525024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.20794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/lary.20794"],"URL":"https:\/\/doi.org\/10.1002\/lary.20794","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,7]]}}}