{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:10:14Z","timestamp":1791382214852,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Hypothesis:<\/jats:title><jats:p>Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking. This study targets the angiogenic process by investigation of tumor expression of MMP\u20102, MMP\u20109, and tissue inhibitors of metalloproteinase (TIMP)\u20101. A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design:<\/jats:title><jats:p>Prospective vestibular schwannoma tissue sampling for ELISA and immunohistochemical determination of MMP\u20102, MMP\u20109 and TIMP\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Thirty\u2010four patients with a sporadic, noncystic, vestibular schwannoma were selected prospectively. Repeated, preoperative magnetic resonance imaging determined the tumor growth pattern. Following translabyrinthine resection, an enzyme\u2010linked immunosorbent assay was used for determination of the MMP\u20102, MMP\u20109, and TIMP\u20101 concentration in tumor sample homogenates. Immunohistochemical labeling was performed in 12 randomly selected tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>All tumor homogenates expressed measurable MMP\u20109, MMP\u20102, and TIMP\u20101. Immunolabeling localized MMP\u20109 expression to the tumor cells, whereas MMP\u20102 and TIMP\u20101 was found interstitially. A significant correlation existed between the concentration MMP\u20109 and absolute tumor growth rate, whereas a weak correlation occurred for the relative growth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Vestibular schwannomas express MMP\u20102, MMP\u20109, and TIMP\u20101 and the tumor concentration of MMP\u20109 correlates with absolute tumor growth rate, but not with age, gender, symptom duration, or preoperative tumor size. No correlations existed between any clinical parameter and MMP\u20102 or TIMP\u20101 expression. We conclude that MMP\u20109 appears to be involved in the growth of vestibular schwannomas. Laryngoscope, 2010<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.20834","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T17:25:06Z","timestamp":1264526706000},"page":"657-662","source":"Crossref","is-referenced-by-count":40,"title":["Angiogenesis in vestibular schwannomas: Expression of extracellular matrix factors MMP\u20102, MMP\u20109, and TIMP\u20101"],"prefix":"10.1002","volume":"120","author":[{"given":"Martin Nue","family":"M\u00f8ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Werther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarnadh","family":"Nalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven\u2010Eric","family":"Stangerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorkild C.","family":"B\u00f8g\u2010Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans 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